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Determination of endocrine-disrupting chemicals in human milk by dispersive liquid–liquid microextraction

    Fernando Vela-Soria

    *Author for correspondence:

    E-mail Address: fervs@ugr.es

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    ,
    Inmaculada Jiménez-Díaz

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    ,
    Caridad Díaz

    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía. Parque Tecnológico de Ciencias de la Salud, Av del Conocimiento, 34, 18016 Armilla, Granada, Spain

    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía. Parque Tecnológico de Ciencias de la Salud, Av del Conocimiento, 34, 18016 Armilla, Granada, Spain

    ,
    José Pérez

    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía. Parque Tecnológico de Ciencias de la Salud, Av del Conocimiento, 34, 18016 Armilla, Granada, Spain

    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía. Parque Tecnológico de Ciencias de la Salud, Av del Conocimiento, 34, 18016 Armilla, Granada, Spain

    ,
    Luz María Iribarne-Durán

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    ,
    Laura Serrano-López

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    ,
    Juan Pedro Arrebola

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    ,
    Mariana Fátima Fernández

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    &
    Nicolás Olea

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain

    CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain

    Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain

    Published Online:https://doi.org/10.4155/bio-2016-0073

    Aim: Human populations are widely exposed to numerous so-called endocrine-disrupting chemicals, exogenous compounds able to interfere with the endocrine system. This exposure has been associated with several health disorders. New analytical procedures are needed for biomonitoring these xenobiotics in human matrices. A quick and inexpensive methodological procedure, based on sample treatment by dispersive liquid–liquid microextraction, is proposed for the determination of bisphenols, parabens and benzophenones in samples. Results: LOQs ranged from 0.4 to 0.7 ng ml-1 and RSDs from 4.3 to 14.8%. Conclusion: This methodology was satisfactorily applied in the simultaneous determination of a wide range of endocrine-disrupting chemicals in human milk samples and is suitable for application in biomonitoring studies.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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