Drug delivery to the ear

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

References

• 1  Scott-Brown’s Otorhinolaryngology. In: Head and Neck Surgery (Seventh Edition). Gleeson M (Ed.). Hodder Arnold Ltd, London, UK (2008).
  Google Scholar
• 2  Nakagawa T, Ito J. Local drug delivery to the inner ears using biodegradeable materials. Ther. Deliv.2,807–814 (2011).▪ Review article covering aspects of inner ear drug delivery.
  CASGoogle Scholar
• 3  Goycoolea MV, Lundman L. Round window membrane structure function and permeability: a review. Microsc. Res. Tech.36,201–211(1997).
  Medline CASGoogle Scholar
• 4  Ishii T, Toriyama M , Suzuki JI. Histopathological study of otitis media with effusion. Ann. Otol. Rhinol. Laryngol. Suppl.89,83–86 (1980).
  Medline CASGoogle Scholar
• 5  Tos M. Pathogenesis and pathology of chronic secretory otits media. Ann. Otol. Rhinol. Laryngol. Suppl.89,91–97 (1980).
  Medline CASGoogle Scholar
• 6  Scottish intercollegiate guidelines network. Diagnosis and Management of Childhood Otitis Media in Primary Care. Scottish intercollegiate guidelines network, Edinburgh, UK, 66 (2006).
  Google Scholar
• 7  Celin SE, Bluestone CD, Stephenson J, Yimaz HM, Collins JJ. Bacteriology of acute Otitis media in adults. JAMA266,2249–2252 (1991).
  Medline CASGoogle Scholar
• 8  Thornsberry C, Sahm DF, Kelly LJ et al. Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumonia, Haemophilus influenza and Moraxella catarrhalis in the United States: results from the TRUST surveillance program 1999–2000. Clin. Infect. Dis.34,S4–S16 (2002).
  MedlineGoogle Scholar
• 9  Woodford N, Livermore DM. Infections caused by Gram-positive bacteria: a review of the global challenge. J. Infect.59(Suppl. 1),S4–S16 (2009).
  MedlineGoogle Scholar
• 10  Pichichero ME, Reed MD. Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media. Paediatr. Drugs11,243–249 (2009).
  MedlineGoogle Scholar
• 11  Mandel EM, Doyle WJ, Winther B, Alper CM. The incidence, prevalence and burden of OM in unselected children aged 1–8 years followed by weekly otoscopy through the ‘common cold’ season. Int. J. Pediatr. Otorhinolaryngol.72,491–499 (2008).
  MedlineGoogle Scholar
• 12  Hall-Stoodley L, Hu FZ, Gieseke A et al. Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA296,202–211(2006).
  Medline CASGoogle Scholar
• 13  Fergie N, Bayston R, Pearson JP, Birchall JP. Is otitis media with effusion a biofilm infection? Clin. Otolaryngol. Allied Sci.29,38–46 (2004).
  Medline CASGoogle Scholar
• 14  Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin. Otolaryngol.25,181–194 (2000).
  Medline CASGoogle Scholar
• 15  Post JC. Direct evidence of bacterial biofilms in otitis media. Laryngoscope111,2083–2094 (2001).
  Medline CASGoogle Scholar
• 16  Daniel M, Rahman C, Ashraf W et al. Development of an in-vitro model of Staphylococcus aureus biofilm infection with a focus on reduced susceptibility to antibiotics. J. Hosp. Infect.76,S4–S5 (2010).
  Google Scholar
• 17  Wilson WR, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch. Otolaryngol.106,772–776 (1980).
  Medline CASGoogle Scholar
• 18  Jackson CG, Glasscock ME 3rd, Davis WE, Hughes GB, Sismanis A. Medical management of Menière’s disease. Ann. Otol. Rhinol. Laryngol.90,142–147 (1981).
  Medline CASGoogle Scholar
• 19  Santos PM, Hall RA, Snyder JM, Hughes LF, Dobie RA. Diuretic and diet effect on Menière’s disease evaluated by the 1985 Committee on Hearing and Equilibrium guidelines. Otolaryngol. Head Neck Surg.109,680–689 (1993).
  Medline CASGoogle Scholar
• 20  Lin CY, Wu JL, Shih TS et al.N-acetyl cysteine against noise induced temporary threshold shift in male workers. Hear. Res.269,42–47 (2010).▪▪ Novel method of antioxidant used to reduce effects of noise-induced hearing loss.
  Medline CASGoogle Scholar
• 21  Huth ME, Ricci AJ, Cheng AG. Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int. J. Otolaryngol.937861 (2011).
  MedlineGoogle Scholar
• 22  Greenwood GJ. Neomycin ototoxicity; report of a case. A.M.A. Arch. Otolaryngol.69,390–397 (1959).
  CASGoogle Scholar
• 23  Fee WE. Aminoglycoside ototoxicity in the human. Laryngoscope90,1–19 (1980).
  MedlineGoogle Scholar
• 24  Mulheran M, Degg C, Burr S, Morgan DW, Stableforth DE. Occurrence and risk of cochleotoxicity in cystic fibrosis patients receiving repeated high-dose aminoglycoside therapy. Antimicrob. Agents Chemotherap.45,2502–2509 (2001).
  Medline CASGoogle Scholar
• 25  Imaimura S, Adams JC. Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J. Assoc. Res. Otolaryngol.4,176–195 (2003).
  MedlineGoogle Scholar
• 26  Kakehata S, Sasaki A, Oji K et al. Comparison of intratympanic and intravenous dexamethasone treatment on sudden sensorineural hearing loss with diabetes. Otol. Neurotol.27,604–608 (2006).
  MedlineGoogle Scholar
• 27  Shea PF, Richey PA, Wan JY, Stevens SR. Hearing results and quality of life after streptomycin/dexamethasone perfusion for Ménière’s disease. Laryngoscope122,204–211 (2012).
  Medline CASGoogle Scholar
• 28  Horie R, Sakamoto T, Nagakawa T et al. Stealth annoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss. Nanomedicine5,1331–1340 (2010).
  Medline CASGoogle Scholar
• 29  Passàli D, Bellussi L, Masieri S. Transtympanic iontophoresis: personal experience. Laryngoscope94,802–806 (1984).▪▪ Novel approach of delivering charged ion particles across an intact tympanic membrane. This study shows future potential.
  Medline CASGoogle Scholar
• 30  Shapiro B, Dormer K, Rutel IB. A two-magnet system to push therapeutic nanoparticles. AIP Conf. Proc.1311,77–88 (2010).▪▪ Novel system of delivering magnetically charged nanoparticles with potential to treat inner ear pathologies.
  MedlineGoogle Scholar
• 31  Chandrasekhar SS. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol. Neurotol.22,18–23(2001).
  Medline CASGoogle Scholar
• 32  Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT. Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope114,1184–1189 (2004).
  Medline CASGoogle Scholar
• 33  Shulman A, Goldstein B. Intratympanic drug therapy with steroids for tinnitus control: a preliminary report. Int. Tinnitus J.6,10–20 (2000).
  Medline CASGoogle Scholar
• 34  Jackson LE, Silverstein H. Chemical perfusion of the inner ear. Otolaryngol. Clin. North Am.35,639–653 (2002).
  MedlineGoogle Scholar
• 35  Berryhill WE, Graham MD. Chemical and physical labyrinthectomy for Ménière’s disease. Otolaryngol. Clin. North Am.35,675–682 (2002).
  MedlineGoogle Scholar
• 36  Yoshioka M, Naganawa S, Sone M, Nakata S, Teranishi M, Nakashima T. Individual differences in the permeability of the round window: evaluating the movement of intratympanic gadolinium into the inner ear. Otol. Neurotol.30,645–648 (2009).
  MedlineGoogle Scholar
• 37  Chen Y, Wen L, Hu P, Qiu J, Lu L, Qiao L. Endoscopic intratympanic methylprednisolone injection for treatment of refractory sudden sensorineural hearing loss and one case in pregnancy. J. Otolaryngol. Head Neck Surg.39,640–645 (2010).
  MedlineGoogle Scholar
• 38  Cesarani A, Capobianco S, Soi D, Giuliano DA, Alpini D. Intratympanic dexamethasone treatment for control of subjective idiopathic tinnitus: our clinical experience. Int. Tinnitus J.8,111–114 (2002).
  Medline CASGoogle Scholar
• 39  Fu Y, Zhao H, Zhang T, Chi F. Intratympanic dexamethasone as initial therapy for idiopathic sudden sensorineural hearing loss: clinical evaluation and laboratory investigations. Auris Nasus Larynx.38,165–171 (2011).
  MedlineGoogle Scholar
• 40  Rauch SD, Halpin CF, Antonelli PJ et al. Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA305,2071–2079 (2011).
  Medline CASGoogle Scholar
• 41  Salt AN, King EB, Hartstock JJ, Gill RM, O’Leary SJ. Marker entry into vestibular perilymph via the stapes following application to the round window niche of guinea pigs. Hear. Res.283,14–23 (2012).
  MedlineGoogle Scholar
• 42  Mikulec AA, Hartstock JJ, Salt AN. Permeability of the round window membrane is influenced by the composition of applied drug solutions and by common surgical procedures. Otol. Neurotol.29,1020–1026 (2008).
  MedlineGoogle Scholar
• 43  Wenzel GI, Warnecke A, Stöver T, Lenarz T. Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. Eur. Arch. Otorhinolaryngol.267,691–699 (2010).
  MedlineGoogle Scholar
• 44  Plontke SK, Löwenheim H, Mertens J et al. Randomized, double blind placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope119,359–369 (2009).
  Medline CASGoogle Scholar
• 45  Plontke SK, Zimmermann R, Zenner HP, Löwenheim H. Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects. Otol. Neurotol.27,912–917 (2006).
  MedlineGoogle Scholar
• 46  Light JP, Silverstein H. Transtympanic perfusion: indications and limitations. Curr. Opin. Otolaryngol. Head Neck Surg.12,378–383(2004).
  MedlineGoogle Scholar
• 47  Suryanarayanan R, Srinivasan VR, O’Sullivan G. Transtympanic gentamicin treatment using Silverstein MicroWick in Ménière’s disease. J. Laryngol. Otol.123,45–49 (2009).
  Medline CASGoogle Scholar
• 48  Hill SL 3rd, Digges EN, Silverstein H. Long term follow-up after gentamicin application via Silverstein MicroWick in the treatment of Ménière’s disease. Ear Nose Throat J.85,494, 496, 498 (2006).
  MedlineGoogle Scholar
• 49  Van Wijk F, Steacker H, Lefebvre PP. Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment. Acta Otolaryngol.127,1012–1017 (2007).
  MedlineGoogle Scholar
• 50  Van Wijck F, Staecker H, Keithley E, Lefebvre PP. Local perfusion of the tumour necrosis factor blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol. Neurootol.11,357–365 (2006).
  MedlineGoogle Scholar
• 51  Al-Zahid S, Daniel M, Chessman R et al. The treatment of glue ear using biodegradable polymers to deliver high dose antibiotics and mucolytics to infection site. Int. J. Surg.9,496 (2011).
  Google Scholar
• 52  Piu F, Wang X, Fernandez R et al. OTO-104: a sustained-release dexamethasone hydrogel for the treatment of otic disorders. Otol. Neurotol.32,171–179 (2011).
  MedlineGoogle Scholar
• 53  Horie RT, Sakamoto T, Nakagawa T et al. Sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid microparticles. Laryngoscope120,377–383 (2010).
  Medline CASGoogle Scholar
• 54  Zou J, Saulnier P, Perrier T et al. Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation. J. Biomed. Mater. Res. B Appl. Biomater.87,10–18 (2008).
  MedlineGoogle Scholar
• 55  Tamura T, Kita T, Nakagawa T et al. Drug delivery to the cochlea using PLGA nanoparticles. Laryngoscope115,2000–2005 (2005).
  Medline CASGoogle Scholar
• 56  Cheper V, Wolf M, Scholl M et al. Potential novel drug carriers for inner ear treatment. Nanomedicine4,623–635 (2009).
  MedlineGoogle Scholar
• 57  McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear.31,156–165 (2010).
  MedlineGoogle Scholar
• 58  Gao X, Want Y, Chen K et al. Magnetic assisted transport of PLGA nanoparticles through a human round window membrane model. J. Nanotechnol. Engin. Med.1(3),031010 (2010).
  Google Scholar
• 59  Philpott C, Gane S, McKiernan D. Nanomedicine in otolaryngology: what does the future hold? Eur. Arch. Otolaryngol.268,489–496 (2011).
  MedlineGoogle Scholar
• 60  Karagama YG, Rashid M, Lancaster JL, Karkanevatos A, William RS. Intranasal delivery of drugs to the Eustachian tube orifice. J. Laryngol. Otol.125,934–939 (2011).
  Medline CASGoogle Scholar
• 61  Chandrasekhar SS, Mautone AJ. Otitis media: treatment with intranasal aerosolized surfactant. Laryngoscope114,472–485 (2004).
  MedlineGoogle Scholar
• 62  Peters G, Lin J, Arriaga MA et al. Middle-ear endoscopy and trans-tympanic drug delivery using an interventional sialendoscope: feasibility study in human cadaveric temporal bones. J. Laryngol. Otol.124,1263–1267 (2010).
  Medline CASGoogle Scholar
• 63  Praetorius M, Limberger A, Müller M et al. A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model. Audiol. Neurootol.6,250–258 (2001).
  Medline CASGoogle Scholar
• 64  Lehner R, Brugger H, Massen MM, Zenner HP. A totally implantable drug delivery system for local therapy of the middle and inner ear. Ear Nose Throat J.76,567–570 (1997).
  Medline CASGoogle Scholar