Enhancing nucleic acid delivery by photochemical internalization

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References

• 1  Juliano RL, Carver K, Cao C, Ming X. Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides. J. Drug Target.21(1),27–43 (2013).
  Medline CASGoogle Scholar
• 2  Lloyd JB. Lysosome membrane permeability: implications for drug delivery. Adv. Drug Deliv. Rev.41(2),189–200 (2000).
  Medline CASGoogle Scholar
• 3  Felgner PL, Gadek TR, Holm M et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl Acad. Sci. USA84(21),7413–7417 (1987).
  Medline CASGoogle Scholar
• 4  Boussif O, Lezoualc’h F, Zanta MA et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA92(16),7297–7301 (1995).
  Medline CASGoogle Scholar
• 5  Read ML, Logan A, Seymour LW. Barriers to gene delivery using synthetic vectors. Adv. Genet.53PA,19–46 (2005).
  MedlineGoogle Scholar
• 6  Sioud M. RNA interference and innate immunity. Adv. Drug Deliv. Rev.59(2–3),153–163 (2007).
  Medline CASGoogle Scholar
• 7  Pirollo KF, Chang EH. Targeted delivery of small interfering RNA: approaching effective cancer therapies. Cancer Res.68(5),1247–1250 (2008).
  Medline CASGoogle Scholar
• 8  Berg K, Selbo PK, Prasmickaite L et al. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res.59(6),1180–1183 (1999).▪▪ First article that describes the photochemical internalization (PCI) method for delivery of macromolecules.
  Medline CASGoogle Scholar
• 9  Stephenson ML, Zamecnik PC. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl Acad. Sci. USA75(1),285–288 (1978).
  Medline CASGoogle Scholar
• 10  Inoue H, Hayase Y, Asaka M et al. Synthesis and properties of novel nucleic acid probes. Nucleic Acids Symp. Ser. (16), 165–168 (1985).
  Google Scholar
• 11  Nielsen PE, Egholm M, Berg RH, Buchardt O. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science254(5037),1497–1500 (1991).
  Medline CASGoogle Scholar
• 12  Koshkin AA, Singh SK, Nielsen P et al. LNA (locked nucleic acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron54,3607–3630 (1998).
  CASGoogle Scholar
• 13  Singh SK, Nielsen P, Koshkin AA, Wengel J. LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition. Chem. Commun.455–456 (1998).
  Google Scholar
• 14  Summerton J, Weller D. Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Dev.7(3),187–195 (1997).
  Medline CASGoogle Scholar
• 15  Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena. Cell31(1),147–157 (1982).
  Medline CASGoogle Scholar
• 16  Mizuno T, Chou MY, Inouye M. Regulation of gene expression by a small RNA transcript (mic RNA) in Escherichia coli K-12. Proc. Jpn. Acad. Sci.59,335–338 (1983).
  CASGoogle Scholar
• 17  Eckstein F. Nucleoside phosphorothioates. Annu. Rev. Biochem.54,367–402 (1985).
  Medline CASGoogle Scholar
• 18  Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.Nature391(6669),806–811 (1998).
  Medline CASGoogle Scholar
• 19  Karkare S, Bhatnagar D. Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino. Appl. Microbiol. Biotechnol.71(5),575–586 (2006).
  Medline CASGoogle Scholar
• 20  Bettinger T, Carlisle RC, Read ML, Ogris M, Seymour LW. Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells. Nucleic Acids Res.29(18),3882–3891 (2001).
  Medline CASGoogle Scholar
• 21  Wolff JA, Malone RW, Williams P et al. Direct gene transfer into mouse muscle in vivo. Science247(4949 Pt 1),1465–1468 (1990).
  Medline CASGoogle Scholar
• 22  Ashley DM, Faiola B, Nair S, Hale LP, Bigner DD, Gilboa E. Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J. Exp. Integr. Med.186(7),1177–1182 (1997).
  Medline CASGoogle Scholar
• 23  Melikov K, Chernomordik LV. Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery. Cell. Mol. Life Sci.62(23),2739–2749 (2005).
  Medline CASGoogle Scholar
• 24  Kopatz I, Remy JS, Behr JP. A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin. J. Gene Med.6(7),769–776 (2004).
  Medline CASGoogle Scholar
• 25  Labat-Moleur F, Steffan AM, Brisson C et al. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther.3(11),1010–1017 (1996).
  Medline CASGoogle Scholar
• 26  De Duve C. Lysosomes. In: Ciba Foundation Symposium. AVS de Reuck, MP Cameron (Eds). Churchill, London, UK 411–412 (1963).
  Google Scholar
• 27  Mukherjee S, Ghosh RN, Maxfield FR. Endocytosis. Physiol. Rev.77(3),759–803 (1997).
  Medline CASGoogle Scholar
• 28  Al-Awqati Q. Proton-translocating ATPases. Annu. Rev. Cell Biol.2,179–199 (1986).
  Medline CASGoogle Scholar
• 29  Bainton DF. The discovery of lysosomes. J. Cell Biol.91(3 Pt 2),66s–76s (1981).
  Medline CASGoogle Scholar
• 30  Berg T, Gjoen T, Bakke O. Physiological functions of endosomal proteolysis. Biochem. J.307(Pt 2),313–326 (1995).
  MedlineGoogle Scholar
• 31  Shiraishi T, Pankratova S, Nielsen PE. Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides. Chem. Biol.12(8),923–929 (2005).
  Medline CASGoogle Scholar
• 32  Dalluge R, Haberland A, Zaitsev S et al. Characterization of structure and mechanism of transfection-active peptide–DNA complexes. Biochim. Biophys. Acta1576(1–2),45–52 (2002).
  Medline CASGoogle Scholar
• 33  Ciftci K, Levy RJ. Enhanced plasmid DNA transfection with lysosomotropic agents in cultured fibroblasts. Int. J. Pharm.218(1–2),81–92 (2001).
  Medline CASGoogle Scholar
• 34  Berg K, Moan J. Lysosomes as photochemical targets. Int. J. Cancer59(6),814–822 (1994).
  Medline CASGoogle Scholar
• 35  Moan J, Berg K, Anholt H, Madslien K. Sulfonated aluminium phthalocyanines as sensitizers for photochemotherapy. Effects of small light doses on localization, dye fluorescence and photosensitivity in V79 cells. Int. J. Cancer58(6),865–870 (1994).
  Medline CASGoogle Scholar
• 36  Gibson SL, Murant RS, Hilf R. Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5´-nucleotidase, Na⁺K⁺-ATPase, and Mg²⁺-ATPase in R3230AC mammary adenocarcinomas. Cancer Res.48(12),3360–3366 (1988).
  Medline CASGoogle Scholar
• 37  Moan J, Johannessen JV, Christensen T, Espevik T, Mcghie JB. Porphyrin-sensitized photoinactivation of human cells in vitro. Am. J. Pathol.109(2),184–192 (1982).
  Medline CASGoogle Scholar
• 38  Boegheim JP, Dubbelman TM, Mullenders LH, Van Steveninck J. Photodynamic effects of haematoporphyrin derivative on DNA repair in murine L929 fibroblasts. Biochem. J.244(3),711–715 (1987).
  Medline CASGoogle Scholar
• 39  Gomer CJ, Rucker N, Banerjee A, Benedict WF. Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative photoradiation, ionizing radiation, or ultraviolet radiation. Cancer Res.43(6),2622–2627 (1983).
  Medline CASGoogle Scholar
• 40  Berns MW, Dahlman A, Johnson FM et al.In vitro cellular effects of hematoporphyrin derivative. Cancer Res.42(6),2325–2329 (1982).
  Medline CASGoogle Scholar
• 41  Hilf R, Murant RS, Narayanan U, Gibson SL. Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. Cancer Res.46(1),211–217 (1986).
  Medline CASGoogle Scholar
• 42  Pass HI. Photodynamic therapy in oncology: mechanisms and clinical use. J. Natl Cancer Inst.85(6),443–456 (1993).
  Medline CASGoogle Scholar
• 43  Mang TS. Lasers and light sources for PDT: past, present and future. Photodiagnosis Photodyn. Ther.1,43–48 (2004).
  MedlineGoogle Scholar
• 44  Selbo PK, Weyergang A, Hogset A et al. Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules. J. Control. Release148(1),2–12 (2010).▪▪ Overview of therapeutic molecules delivered by PCI.
  Medline CASGoogle Scholar
• 45  Foote C. Type I and Type II mechanisms of photodynamic action. In: Light-Activated Pesticides. Heitz JR, Downnum KR (Eds). American Chemical Society, Washington, DC, USA, 22–38 (1987).
  Google Scholar
• 46  Spikes JD. Photobiology of porphyrins. Prog. Clin. Biol. Res.170,19–39 (1984).
  Medline CASGoogle Scholar
• 47  Moan J, Berg K. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol.53(4),549–553 (1991).
  Medline CASGoogle Scholar
• 48  Hallett FR, Hallett BP, Snipes W. Reactions between singlet oxygen and the constituents of nucleic acids. Importance of reactions in photodynamic processes. Biophys. J.10(4),305–315 (1970).
  Medline CASGoogle Scholar
• 49  Berg K, Western A, Bommer JC, Moan J. Intracellular localization of sulfonated meso-tetraphenylporphines in a human carcinoma cell line. Photochem. Photobiol.52(3),481–487 (1990).
  Medline CASGoogle Scholar
• 50  Moan J, Berg K, Kvam E et al. Intracellular localization of photosensitizers. Ciba Found. Symp.146,95–107; discussion 107–111 (1989).
  Medline CASGoogle Scholar
• 51  Moan J, Berg K, Bommer JC, Western A. Action spectra of phthalocyanines with respect to photosensitization of cells. Photochem. Photobiol.56(2),171–175 (1992).
  Medline CASGoogle Scholar
• 52  Maman N, Dhami S, Phillips D, Brault D. Kinetic and equilibrium studies of incorporation of di-sulfonated aluminum phthalocyanine into unilamellar vesicles. Biochim. Biophys. Acta1420(1–2),168–178 (1999).
  Medline CASGoogle Scholar
• 53  Prasmickaite L, Hogset A, Berg K. Evaluation of different photosensitizers for use in photochemical gene transfection. Photochem. Photobiol.73(4),388–395 (2001).▪▪ Investigation of various photosensitizers for use in PCI.
  Medline CASGoogle Scholar
• 54  Engesaeter BO, Tveito S, Bonsted A, Engebraaten O, Berg K, Maelandsmo GM. Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus. J. Gene Med.8(6),707–718 (2006).
  Medline CASGoogle Scholar
• 55  Nishiyama N, Iriyama A, Jang WD et al. Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater.4(12),934–941 (2005).▪ A novel dendrimeric photosensitizer for PCI.
  Medline CASGoogle Scholar
• 56  Shieh MJ, Peng CL, Lou PJ et al. Non-toxic phototriggered gene transfection by PAMAM-porphyrin conjugates. J. Control. Release129(3),200–206 (2008).
  Medline CASGoogle Scholar
• 57  Gaware VS, Hakerud M, Leosson K et al. Tetraphenylporphyrin tethered chitosan based carriers for photochemical transfection. J. Med. Chem.56(3),807–819 (2013).
  Medline CASGoogle Scholar
• 58  Boe SL, Longva AS, Hovig E. A novel photosensitizer for light-controlled gene silencing. Nucleic Acid Ther.21(5),359–367 (2011).
  Medline CASGoogle Scholar
• 59  Peng Q, Moan J. Correlation of distribution of sulphonated aluminium phthalocyanines with their photodynamic effect in tumour and skin of mice bearing CaD2 mammary carcinoma. Br. J. Cancer72(3),565–574 (1995).
  Medline CASGoogle Scholar
• 60  Peng Q, Moan J, Cheng LS. The effect of glucose administration on the uptake of photofrin II in a human tumor xenograft. Cancer Lett.58(1–2),29–35 (1991).
  Medline CASGoogle Scholar
• 61  Henderson BW, Bellnier DA. Tissue localization of photosensitizers and the mechanism of photodynamic tissue destruction. Ciba Found. Symp.146,112–125; discussion 125–130 (1989).
  Medline CASGoogle Scholar
• 62  Freitas I. Lipid accumulation: the common feature to photosensitizer-retaining normal and malignant tissues. J. Photochem. Photobiol.7(2–4),359–361 (1990).
  Medline CASGoogle Scholar
• 63  Musser DA, Wagner JM, Weber FJ, Datta-Gupta N. The binding of tumor localizing porphyrins to a fibrin matrix and their effects following photoirradiation. Res. Commun. Chem. Pathol. Pharmacol.28(3),505–525 (1980).
  Medline CASGoogle Scholar
• 64  Van Dongen GA, Visser GW, Vrouenraets MB. Photosensitizer-antibody conjugates for detection and therapy of cancer. Adv. Drug Deliv. Rev.56(1),31–52 (2004).
  Medline CASGoogle Scholar
• 65  Demidov VV, Potaman VN, Frank-Kamenetskii MD et al. Stability of peptide nucleic acids in human serum and cellular extracts. Biochem. Pharmacol.48(6),1310–1313 (1994).
  Medline CASGoogle Scholar
• 66  Egholm MB, Nielsen PE, Buchardt O, Berg RH. Recognition of guanine and adenine in DNA by thymine and cytosine containing peptide nucleic acids. J. Am. Chem. Soc.114,9677–9678 (1992).
  CASGoogle Scholar
• 67  Egholm MB, Nielsen PE, Buchardt O, Berg RH. Peptide nucleic acids (PNA). Oligonucleotide analogues with an achiral peptide backbone. J. Am. Chem. Soc.114,1895–1897 (1992).
  CASGoogle Scholar
• 68  Egholm M, Buchardt O, Christensen L et al. PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules. Nature365(6446),566–568 (1993).
  Medline CASGoogle Scholar
• 69  Hanvey JC, Peffer NJ, Bisi JE et al. Antisense and antigene properties of peptide nucleic acids. Science258(5087),1481–1485 (1992).
  Medline CASGoogle Scholar
• 70  Ray A, Norden B. Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J.14(9),1041–1060 (2000).
  Medline CASGoogle Scholar
• 71  Boffa LC, Cutrona G, Cilli M et al. Inhibition of Burkitt’s lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc. Cancer Gene Ther.14(2),220–226 (2007).
  Medline CASGoogle Scholar
• 72  Pooga M, Soomets U, Hallbrink M et al. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol.16(9),857–861 (1998).
  Medline CASGoogle Scholar
• 73  Tyler BM, Mccormick DJ, Hoshall CV et al. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo. FEBS Lett.421(3),280–284 (1998).
  Medline CASGoogle Scholar
• 74  Sazani P, Gemignani F, Kang SH et al. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat. Biotechnol.20(12),1228–1233 (2002).
  Medline CASGoogle Scholar
• 75  Yin H, Lu Q, Wood M. Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice. Mol. Ther.16(1),38–45 (2008).
  Medline CASGoogle Scholar
• 76  Wang G, Xu X, Pace B et al. Peptide nucleic acid (PNA) binding-mediated induction of human gamma-globin gene expression. Nucleic Acids Res.27(13),2806–2813 (1999).
  Medline CASGoogle Scholar
• 77  Karras JG, Maier MA, Lu T, Watt A, Manoharan M. Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain. Biochemistry40(26),7853–7859 (2001).
  Medline CASGoogle Scholar
• 78  Shammas MA, Simmons CG, Corey DR, Shmookler Reis RJ. Telomerase inhibition by peptide nucleic acids reverses ‘immortality’ of transformed human cells. Oncogene18(46),6191–6200 (1999).
  Medline CASGoogle Scholar
• 79  Hamilton SE, Simmons CG, Kathiriya IS, Corey DR. Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol.6(6),343–351 (1999).
  Medline CASGoogle Scholar
• 80  Herbert B, Pitts AE, Baker SI et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl Acad. Sci. USA96(25),14276–14281 (1999).
  Medline CASGoogle Scholar
• 81  Doyle DF, Braasch DA, Simmons CG, Janowski BA, Corey DR. Inhibition of gene expression inside cells by peptide nucleic acids: effect of mRNA target sequence, mismatched bases, and PNA length. Biochemistry40(1),53–64 (2001).
  Medline CASGoogle Scholar
• 82  Uhlmann E. Peptide nucleic acids (PNA) and PNA-DNA chimeras: from high binding affinity towards biological function. Biol. Chem.379(8–9),1045–1052 (1998).
  Medline CASGoogle Scholar
• 83  Simmons CG, Pitts AE, Mayfield LD, Shay JW, Corey DR. Synthesis and membrane permeability of PNA-peptide conjugates Bioorg. Med. Chem. Lett.7,3001–3006 (1997).
  CASGoogle Scholar
• 84  Aldrian-Herrada G, Desarmenien MG, Orcel H et al. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons. Nucleic Acids Res.26(21),4910–4916 (1998).
  Medline CASGoogle Scholar
• 85  Ljungstrom T, Knudsen H, Nielsen PE. Cellular uptake of adamantyl conjugated peptide nucleic acids. Bioconj. Chem.10(6),965–972 (1999).
  Medline CASGoogle Scholar
• 86  Mologni L, Marchesi E, Nielsen PE, Gambacorti-Passerini C. Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid. Cancer Res.61(14),5468–5473 (2001).
  Medline CASGoogle Scholar
• 87  Koppelhus U, Awasthi SK, Zachar V, Holst HU, Ebbesen P, Nielsen PE. Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates. Antisense Nucleic Acid Drug Dev.12(2),51–63 (2002).
  Medline CASGoogle Scholar
• 88  Abes S, Williams D, Prevot P, Thierry A, Gait MJ, Lebleu B. Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates. J. Control. Release110(3),595–604 (2006).
  Medline CASGoogle Scholar
• 89  Shiraishi T, Nielsen PE. Photochemically enhanced cellular delivery of cell penetrating peptide–PNA conjugates. FEBS Lett.580(5),1451–1456 (2006).
  Medline CASGoogle Scholar
• 90  Boe S, Hovig E. Photochemically induced gene silencing using PNA-peptide conjugates. Oligonucleotides16(2),145–157 (2006).
  Medline CASGoogle Scholar
• 91  Folini M, Berg K, Millo E et al. Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Res.63(13),3490–3494 (2003).
  Medline CASGoogle Scholar
• 92  Folini M, Bandiera R, Millo E et al. Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells. Cell Prolif.40(6),905–920 (2007).
  Medline CASGoogle Scholar
• 93  Sei S, Yang QE, O’Neill D, Yoshimura K, Nagashima K, Mitsuya H. Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain. J. Virol.74(10),4621–4633 (2000).
  Medline CASGoogle Scholar
• 94  Cutrona G, Carpaneto EM, Ulivi M et al. Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal. Nat. Biotechnol.18(3),300–303 (2000).
  Medline CASGoogle Scholar
• 95  Shiraishi T, Nielsen PE. Nanomolar cellular antisense activity of peptide nucleic acid (PNA) cholic acid (‘umbrella’) and cholesterol conjugates delivered by cationic lipids. Bioconj. Chem.23(2),196–202 (2012).
  Medline CASGoogle Scholar
• 96  Shiraishi T, Hamzavi R, Nielsen PE. Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells. Nucleic Acids Res.36(13),4424–4432 (2008).
  Medline CASGoogle Scholar
• 97  Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature411(6836),494–498 (2001).
  Medline CASGoogle Scholar
• 98  Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Develop.15(2),188–200 (2001).
  Medline CASGoogle Scholar
• 99  Boe S, Longva AS, Hovig E. Photochemically induced gene silencing using small interfering RNA molecules in combination with lipid carriers. Oligonucleotides17(2),166–173 (2007).
  Medline CASGoogle Scholar
• 100  Oliveira S, Fretz MM, Hogset A, Storm G, Schiffelers RM. Photochemical internalization enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA. Biochim. Biophys. Acta1768(5),1211–1217 (2007).
  Medline CASGoogle Scholar
• 101  Oliveira S, Hogset A, Storm G, Schiffelers RM. Delivery of siRNA to the target cell cytoplasm: photochemical internalization facilitates endosomal escape and improves silencing efficiency, in vitro and in vivo. Curr. Pharm. Des.14(34),3686–3697 (2008).▪▪ Proof-of-concept study showing in vivo delivery of siRNA by PCI.
  Medline CASGoogle Scholar
• 102  Jorgensen JA, Longva AS, Hovig E, Boe SL. Evaluation of biodegradable peptide carriers for light-directed targeting. Nucleic Acid Ther.23(2),131–139 (2013).▪ Demonstrates effective PCI-induced siRNA targeting by peptide carriers.
  Medline CASGoogle Scholar
• 103  Lu D, Benjamin R, Kim M, Conry RM, Curiel DT. Optimization of methods to achieve mRNA-mediated transfection of tumor cells in vitro and in vivo employing cationic liposome vectors. Cancer Gene Ther.1(4),245–252 (1994).
  Medline CASGoogle Scholar
• 104  Kariko K, Kuo A, Barnathan E. Overexpression of urokinase receptor in mammalian cells following administration of the in vitro transcribed encoding mRNA. Gene Ther.6(6),1092–1100 (1999).
  Medline CASGoogle Scholar
• 105  Felgner PL, Ringold GM. Cationic liposome-mediated transfection. Nature337(6205),387–388 (1989).
  Medline CASGoogle Scholar
• 106  Malone RW, Felgner PL, Verma IM. Cationic liposome-mediated RNA transfection. Proc. Natl Acad. Sci. USA86(16),6077–6081 (1989).
  Medline CASGoogle Scholar
• 107  Hecker JG, Hall LL, Irion VR. Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system. Mol. Ther.3(3),375–384 (2001).
  Medline CASGoogle Scholar
• 108  Fisher KJ, Wilson JM. The transmembrane domain of diphtheria toxin improves molecular conjugate gene transfer. Biochem. J.321(Pt 1),49–58 (1997).
  Medline CASGoogle Scholar
• 109  Nair SK, Boczkowski D, Morse M, Cumming RI, Lyerly HK, Gilboa E. Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat. Biotechnol.16(4),364–369 (1998).
  Medline CASGoogle Scholar
• 110  Boe S, Saeboe-Larssen S, Hovig E. Light-induced gene expression using messenger RNA molecules. Oligonucleotides20(1),1–6 (2010).▪ The possibility of effective PCI-induced mRNA delivery for gain-of-function studies.
  Medline CASGoogle Scholar
• 111  Boe SL, Jorgensen JA, Longva AS, Lavelle T, Saeboe-Larssen S, Hovig E. Light-controlled modulation of gene expression using polyamidoamine formulations. Nucleic Acid Ther.23(2),160–165 (2013).
  Medline CASGoogle Scholar
• 112  Prasmickaite L, Hogset A, Olsen VM, Kaalhus O, Mikalsen SO, Berg K. Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir. Cancer Gene Ther.11(7),514–523 (2004).
  Medline CASGoogle Scholar
• 113  Ndoye A, Merlin JL, Leroux A et al. Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI–DNA complexes. J. Gene Med.6(8),884–894 (2004).
  Medline CASGoogle Scholar
• 114  Maurice-Duelli A, Ndoye A, Bouali S, Leroux A, Merlin JL. Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalization in endometrial cancer cells. Technol. Cancer Res. Treat3(5),459–465 (2004).
  Medline CASGoogle Scholar
• 115  Nishiyama N, Arnida, Jang WD, Date K, Miyata K, Kataoka K: Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target.14(6),413–424 (2006).
  Medline CASGoogle Scholar
• 116  Kloeckner J, Prasmickaite L, Hogset A, Berg K, Wagner E. Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes. J. Drug Target.12(4),205–213 (2004).
  Medline CASGoogle Scholar
• 117  Boe S, Longva AS, Hovig E. Evaluation of various polyethylenimine formulations for light-controlled gene silencing using small interfering RNA molecules. Oligonucleotides18,23–32 (2008).▪ Demonstrates how to optimize parameters for effective PCI-induced siRNA targeting.
  Google Scholar
• 118  Boe SL, Longva AS, Hovig E. Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing. Oligonucleotides20(4),175–182 (2010).
  Medline CASGoogle Scholar
• 119  Hogset A, Prasmickaite L, Tjelle TE, Berg K. Photochemical transfection: a new technology for light-induced, site-directed gene delivery. Hum. Gene Ther.11(6),869–880 (2000).
  Medline CASGoogle Scholar
• 120  De Paula D, Bentley MV, Mahato RI. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA13(4),431–456 (2007).
  Medline CASGoogle Scholar
• 121  Lai PS, Pai CL, Peng CL, Shieh MJ, Berg K, Lou PJ. Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization. J. Biomed. Mater. Res. A87(1),147–155 (2008).
  MedlineGoogle Scholar
• 122  Cabral H, Nakanishi M, Kumagai M, Jang WD, Nishiyama N, Kataoka K. A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles. Pharm. Res.26(1),82–92 (2009).
  Medline CASGoogle Scholar
• 123  Lai PS, Lou PJ, Peng CL et al. Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J. Control. Release122(1),39–46 (2007).
  Medline CASGoogle Scholar
• 124  Bae KH, Lee JY, Lee SH, Park TG, Nam YS. Optically traceable solid lipid nanoparticles loaded with siRNA and paclitaxel for synergistic chemotherapy with in situ imaging. Adv. Healthc. Mater.2(4),576–584 (2013).
  Medline CASGoogle Scholar
• 125  Raemdonck K, Naeye B, Buyens K et al. Biodegradable dextran nanogels for RNA interference: focusing on endosomal escape and intracellular siRNA delivery. Adv. Funct. Mater. (19), 1–10 (2009).
  Google Scholar
• 126  Varkouhi AK, Schiffelers RM, Van Steenbergen MJ, Lammers T, Hennink WE, Storm G. Photochemical internalization (PCI)-mediated enhancement of gene silencing efficiency of polymethacrylates and N,N,N-trimethylated chitosan (TMC) based siRNA polyplexes. J. Control. Release148(1),e98–e99 (2010).
  Medline CASGoogle Scholar
• 127  Jin H, Lovell JF, Chen J et al. Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization. Photochem. Photobiol. Sci.10(5),810–816 (2011).
  Medline CASGoogle Scholar
• 128  Jorgensen JA, Hovig E, Boe SL. Potent gene silencing in vitro at physiological pH using chitosan polymers. Nucleic Acid Ther.22(2),96–102 (2012).
  Medline CASGoogle Scholar
• 129  Ndoye A, Dolivet G, Hogset A et al. Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization. Mol. Ther.13(6),1156–1162 (2006).
  Medline CASGoogle Scholar
• 130  Hellum M, Hogset A, Engesaeter BO et al. Photochemically enhanced gene delivery with cationic lipid formulations. Photochem. Photobiol. Sci.2(4),407–411 (2003).
  Medline CASGoogle Scholar
• 131  Prasmickaite L, Hogset A, Tjelle TE, Olsen VM, Berg K. Role of endosomes in gene transfection mediated by photochemical internalisation (PCI). J. Gene Med.2(6),477–488 (2000).
  Medline CASGoogle Scholar
• 132  Dietze A, Bonsted A, Hogset A, Berg K. Photochemical internalization enhances the cytotoxic effect of the protein toxin gelonin and transgene expression in sarcoma cells. Photochem. Photobiol.78(3),283–289 (2003).
  Medline CASGoogle Scholar
• 133  Prasmickaite L, Hogset A, Berg K. The role of the cell cycle on the efficiency of photochemical gene transfection. Biochim. Biophys. Acta1570(3),210–218 (2002).
  Medline CASGoogle Scholar
• 134  Arnida, Nishiyama N, Kanayama N, Jang WD, Yamasaki Y, Kataoka K. PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection. J. Control. Release115(2),208–215 (2006).
  MedlineGoogle Scholar
• 135  Gargouri M, Sapin A, Arica-Yegin B, Merlin JL, Becuwe P, Maincent P. Photochemical internalization for pDNA transfection: evaluation of poly(d,l-lactide-co-glycolide) and poly(ethylenimine) nanoparticles. Int. J. Pharm.403(1–2),276–284 (2011).
  Medline CASGoogle Scholar
• 136  Garaiova Z, Strand SP, Reitan NK et al. Cellular uptake of DNA–chitosan nanoparticles: the role of clathrin- and caveolae-mediated pathways. Int. J. Biol. Macromol.51(5),1043–1051 (2012).
  Medline CASGoogle Scholar
• 137  Prasmickaite L, Hellum M, Kaalhus O, Hogset A, Wagner E, Berg K. Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter. Photochem. Photobiol.82(3),809–816 (2006).
  Medline CASGoogle Scholar