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Efficient extraction method using magnetic carbon nanotubes to analyze cocaine and benzoylecgonine in breast milk by GC/MS

    Rosimeire Resende dos Santos

    Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte; Brasil, MG, 31270–901, Brazil

    ,
    Maria José Nunes Paiva

    Departamento de Farmácia, Universidade Federal de São João Del-Rei, Divinópolis, MG, 35501296, Brazil

    ,
    Júlio César Veloso

    Departamento de Farmácia, Universidade Federal de São João Del-Rei, Divinópolis, MG, 35501296, Brazil

    ,
    Philippe Serp

    Laboratoire de Chimie de Coordination UPR CNRS 8241, composante ENSIACET, Université de Toulouse UPS-INP-LCC 4 allée Emile Monso BP 44362, 31030 Toulouse Cedex 4, France

    ,
    Zenilda de Lourdes Cardeal

    Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte; Brasil, MG, 31270–901, Brazil

    &
    Helvécio Costa Menezes

    *Author for correspondence: Tel.: +55 3134095725; Fax: +55 3134095700;

    E-mail Address: hmenezes@ufmg.br

    Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte; Brasil, MG, 31270–901, Brazil

    Published Online:https://doi.org/10.4155/bio-2017-0140

    Aim: The increasing use of cocaine (COC) during breastfeeding has led to growing concern about exposure of infants. Therefore, to study this exposure, a new method to analyze COC and benzoylecgonine in breast milk was developed. Methodology: A new extraction method was used for the first time to analyze COC and its major metabolite, benzoylecgonine, in breast milk using magnetic carbon nanotubes partially doped with nitrogen. Results: The calibration curves were linear in the range 5.0–180.0 ng ml-1. The limit of quantification was 5.0 ng ml-1. Coefficients of variation were between 3.2 and 13.9%. Recovery was between 89.6 and 99.2%. Conclusion: The proposed method is simple, efficient and suitable to determine analytes in breast milk.

    Papers of special note have been highlighted as: • of interest

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