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Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples

    Xiaoyue Shan‡

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ‡Authors contributed equally and should be considered as co-first authors

    Search for more papers by this author

    ,
    Lei Zhang‡

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ‡Authors contributed equally and should be considered as co-first authors

    Search for more papers by this author

    ,
    Haipeng Ye

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ,
    Ji Shao

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ,
    Yanpeng Shi

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ,
    Siwei Tan

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    ,
    Ling Zhang

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    &
    Kewen Su

    *Author for correspondence: Tel.: +86 571 851 31787;

    E-mail Address: sukewenzfy@163.com

    Hangzhou Occupational Disease Prevention & Control Hospital, Hangzhou 310014, China

    Published Online:https://doi.org/10.4155/bio-2021-0180

    Quantification of hippuric acid and methylhippuric acid in human urine matrices provides information on the toluene and xylene exposure conditions. High performance liquid chromatography coupled with UV detection is the preferable technique for hippuric acid and methylhippuric acid detection in human urine. This study was conducted to present analytical techniques developed for monitoring of hippuric acid and methylhippuric acid in human urine matrices during 2016–2021.

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