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Research Article

A smartphone digital image colorimetric method based on nanoparticles for determination of lamotrigine

    Yasaman Sefid-Sefidehkhan

    Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, 1313156199, Iran

    ,
    Mehdi Mokhtari

    Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    ,
    Abolghasem Jouyban

    Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Faculty of Pharmacy, Near East University, Nicosia, North Cyprus, 99138, Mersin 10, Turkey

    ,
    Maryam Khoshkam

    Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, 1313156199, Iran

    ,
    Maryam Khoubnasabjafari

    Department of Anesthesiology and Intensive Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    ,
    Vahid Jouyban-Gharamaleki

    Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    &
    Elaheh Rahimpour

    *Author for correspondence:

    E-mail Address: rahimpour_e@yahoo.com

    Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran

    Published Online:https://doi.org/10.4155/bio-2023-0075

    Aim: A colorimetric approach for quantification of lamotrigine using spectrophotometric and smartphone image analysis is described in this study. Methods: For full optimization and validation procedures, UV-visible spectroscopy was used, and image analysis was carried out with the help of an app (PhotoMetrix PRO®). Then, as a multivariate calibration method, parallel factor analysis was used for data analysis. Results: The results demonstrated the capacity of these methods to estimate lamotrigine concentrations in the range of 0.1–7.0 μg.ml-1 in exhaled breath condensate, indicating the value of using digital images and smartphone applications in combination with chemometric tools. Conclusion: The image analysis can be superior for its fast and reliable lamotrigine analysis in biological samples.

    Tweetable abstract

    A smartphone digital image colorimetric method for lamotrigine.

    Papers of special note have been highlighted as: • of interest

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