We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×

Capillary plasma separation microsampling devices: a solution for dried blood spot limitations in clinical testing

    Amanda Pacheco Bondan

    Laboratory of Analytical Toxicology, Universidade Feevale, Rua Rubem Berta, No. 200, CEP 93525-080, Novo Hamburgo, Brazil

    &
    Rafael Linden

    *Author for correspondence:

    E-mail Address: rafael.linden@feevale.br

    Laboratory of Analytical Toxicology, Universidade Feevale, Rua Rubem Berta, No. 200, CEP 93525-080, Novo Hamburgo, Brazil

    Published Online:https://doi.org/10.4155/bio-2023-0109
    Free first page

    References

    • 1. Antunes MV, Charão MF, Linden R. Dried blood spots analysis with mass spectrometry: potentials and pitfalls in therapeutic drug monitoring. Clin. Biochem. 49(13–14), 1035–1046 (2016).
    • 2. Capiau S, Veenhof H, Koster RA et al. Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: development and validation of dried blood spot-based methods for therapeutic drug monitoring. Ther. Drug Monit. 41(4), 409–430 (2019).
    • 3. Delahaye L, Veenhof H, Koch BCP, Alffenaar JWC, Linden R, Stove C. Alternative sampling devices to collect dried blood microsamples: state-of-the-art. Ther. Drug Monit. 43(3), 310–321 (2021).
    • 4. Baillargeon KR, Mace CR. Microsampling tools for collecting, processing, and storing blood at the point-of-care. Bioeng. Transl. Med. 8, e10476 (2023).
    • 5. Rowland M, Emmons GT. Use of dried blood spots in drug development: pharmacokinetic considerations. AAPS J. 12(3), 290–293 (2010).
    • 6. Corso G, Papagni F, Gelzo M et al. Development and validation of an enzymatic method for total cholesterol analysis using whole blood spot. J. Clin. Lab. Anal. 30(5), 517–523 (2016).
    • 7. Kupke IR, Zeugner S, Gottschalk A, Kather B. Differences in lipid and lipoprotein concentrations of capillary and venous blood samples. Clin. Chim. Acta 97(2–3), 279–283 (1979).
    • 8. Crawford ML, Collier BB, Bradley MN, Holland PL, Shuford CM, Grant RP. Empiricism in microsampling: utilizing a novel lateral flow device and intrinsic normalization to provide accurate and precise clinical analysis from a finger stick. Clin. Chem. 66(6), 821–831 (2020).
    • 9. Shuford CM, McConnell EW, Dee S, Grant RP. Pre-analytical conditions influencing analysis of folate in dried plasma microsamples. J. Mass Spectrom. Adv. Clin. Lab. 28, 1–8 (2023).
    • 10. Silliman E, Chung EH, Fitzpatrick E et al. Evaluation of at-home serum anti-Müllerian hormone testing: a head-to-head comparison study. Reprod. Biol. Endocrinol. 20(1), 1–11 (2022).
    • 11. Kaiser NK, Steers M, Nichols CM, Mellert H, Pestano GA. Design and characterization of a novel blood collection and transportation device for proteomic applications. Diagnostics 10(12), 1032 (2020).
    • 12. Linden G, Charão MF, Linden R. Evaluation of the HealthID PSD microsampling device for the simultaneous determination of cholesterol, high-density lipoprotein, triglycerides, creatinine, and HbA1c in capillary blood. Clin. Biochem. 110597 (2023). https://doi.org/10.1016/j.clinbiochem.2023.110597
    • 13. Carmona S, Seiverth B, Magubane D, Hans L, Hoppler M. Separation of plasma from whole blood by use of the cobas plasma separation card: a compelling alternative to dried blood spots for quantification of HIV-1 viral load. J. Clin. Microbiol. 57(4), e01336–18 (2018).
    • 14. Kim JH, Woenker T, Adamec J, Regnier FE. Simple, miniaturized blood plasma extraction method. Anal. Chem. 85(23), 11501–11508 (2013).