Review

Modern bioanalytical methods for the rapid detection of antidepressants: SNRIs and SSRIs in human biological samples

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Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 541 24, Greece.

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Email the corresponding author at samanidu@chem.auth.gr

Paraskevi Kourti

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, 541 24, Greece.

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Email the corresponding author at samanidu@chem.auth.gr

Published Online:11 Jun 2009https://doi.org/10.4155/bio.09.38

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Abstract

Serotonin–norepinephrine-reuptake inhibitors (SNRIs) and selective serotonin-reuptake inhibitors (SSRIs) belong to a new generation of antidepressants used in the treatment of depression and other mood disorders. SSRIs act as reuptake inhibitors primarily via the inhibition of the neuronal reuptake of serotonin (5-HT) in the CNS. SNRIs have additional inhibitory activity at noradrenaline-reuptake sites. Different analytical methods for the routine monitoring and toxicological screening of SNRIs and SSRIs have been developed. Rapid quantification is a necessity for clinical use, allowing the possibility of diagnostics. This review focuses on recent advances of the methods that concern the determination of SSRIs and SNRIs in human biological samples. Sample preparation methodologies are discussed, because sample pretreatment is the most limiting and crucial step in analysis of biological matrices. Furthermore, information concerning the mechanism of action, side effects and toxicity are also given.

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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