High-resolution mass spectrometry will dramatically change our drug-discovery bioanalysis procedures
Bibliography
- 1 Korfmacher W. Bioanalytical assays in a drug discovery environment. In: Using Mass Spectrometry for Drug Metabolism Studies. Korfmacher W (Ed.). CRC Press, Boca Raton, FL, USA 1–34 (2005).Google Scholar
- 2 Korfmacher WA. Principles and applications of LC–MS in new drug discovery. Drug Discov. Today10(20),1357–1367 (2005).Crossref, Medline, CAS, Google Scholar
- 3 Korfmacher WA, Cox KA, Bryant MS, Veals J, Ng K, Lin CC. HPLC–API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process. Drug Discov. Today2,532–537 (1997).Crossref, CAS, Google Scholar
- 4 Yu K, Little D, Plumb R, Smith B. High-throughput quantification for a drug mixture in rat plasma – a comparison of ultra performance liquid chromatography/tandem mass spectrometry with high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom.20(4),544–552 (2006).Crossref, Medline, CAS, Google Scholar
- 5 Wainhaus S. Fast chromatography with UPLC and other techniques. In: Using Mass Spectrometry for Drug Metabolism Studies (Second Edition). Korfmacher W (Ed.). CRC Press, Boca Raton, FL, USA 255–275 (2010).Google Scholar
- 6 Wainhaus S, Nardo C, Anstatt R, Wang S, Dunn-Meynell K, Korfmacher W. Ultra fast liquid chromatography-MS/MS for pharmacokinetic and metabolic profiling within drug discovery. Am. Drug Discov.2(1),6–12 (2007).Google Scholar
- 7 Korfmacher WA. Advances in the integration of drug metabolism into the lead optimization paradigm. Mini Rev. Med. Chem.9(6),703–716 (2009).Crossref, Medline, CAS, Google Scholar
- 8 Zhang NR, Yu S, Tiller P, Yeh S, Mahan E, Emary WB. Quantitation of small molecules using high-resolution accurate mass spectrometers – a different approach for analysis of biological samples. Rapid Commun. Mass Spectrom.23(7),1085–1094 (2009).Crossref, Medline, CAS, Google Scholar
- 9 Bateman KP, Kellmann M, Muenster H, Papp R, Taylor L. Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer. J. Am. Soc. Mass Spectrom.20(8),1441–1450 (2009).Crossref, Medline, CAS, Google Scholar
- 10 Kaufmann A, Butcher P, Maden K, Walker S, Widmer M. Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared with tandem mass spectrometry. Rapid Commun. Mass Spectrom.25(7),979–992 (2011).Crossref, Medline, CAS, Google Scholar
- 11 Kerns E, Di L. Drug-like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Elsevier/Academic Press, NY, USA (2008).Google Scholar
- 12 Zhang H, Ma L, He K, Zhu M. An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine. J. Mass Spectrom.43(9),1191–1200 (2008).Crossref, Medline, CAS, Google Scholar
- 13 Zhu M, Ma L, Zhang D et al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab. Dispos.34(10),1722–1733 (2006).Crossref, Medline, CAS, Google Scholar
- 101 Biocius Life Sciences. www.biocius.com/pr/rf360_high_resolution_time_of_flight_mass_spec_ADME_screening.htmlGoogle Scholar

