Review

SERS-based approaches toward genetic profiling

Agampodi Swarnapali De Silva Indrasekara

Department of Materials Science & Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, USA

*Author for correspondence:

Department of Materials Science & Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, USA

Institute for Advanced Materials Devices & Nanotechnology, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, USA

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Published Online:14 Jan 2015https://doi.org/10.4155/bio.14.295

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Abstract

In the last decade surface-enhanced Raman scattering (SERS) has experienced an important resurgence, and as a consequence it has seen wide application in the biological field, especially for DNA identification. SERS-based DNA detection can be carried out directly and indirectly and, in the latter approach, it relies on the use of SERS tags, whose role is to indirectly prove the recognition and binding of a specific oligonucleotide sequence. Herein, the role of SERS tags is analyzed focusing specifically on the use of DNA identification for genetic profiling.

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Published online 14 January 2015

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The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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