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Special Focus: Antifungal drug discovery – Editorial

How promising are combinatorial drug strategies in combating Candida albicans biofilms?

    Karin Thevissen

    *Author for correspondence:

    E-mail Address: karin.thevissen@biw.kuleuven.be

    Centre for Microbial & Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium

    Published Online:https://doi.org/10.4155/fmc-2016-0127
    Free first page

    References

    • 1 Progress report 2014 of Transatlantic Task Force on antimicrobial resistance (TATFAR). www.cdc.gov/drugresistance/pdf/tatfar-progress_report_2014.pdf.
    • 2 Shallcross LJ, Howard SJ, Fowler T, Davies SC. Tackling the threat of antimicrobial resistance: from policy to sustainable action. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370(1670), 20140082 (2015).
    • 3 Muzny CA, Schwebke JR. Biofilms: an underappreciated mechanism of treatment failure and recurrence in vaginal infections. Clin. Infect. Dis. 61(4), 601–606 (2015).
    • 4 Davies D. Understanding biofilm resistance to antibacterial agents. Nat. Rev. Drug Discov. 2(2), 114–122 (2003).
    • 5 Lafleur MD, Qi Q, Lewis K. Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrob. Agents Chemother. 54(1), 39–44 (2010).
    • 6 Ramage G, Williams C. The clinical importance of fungal biofilms. Adv. Appl. Microbiol. 84, 27–83 (2013).
    • 7 Nett JE. The host's reply to Candida biofilm. Pathogens 5(1), pii: E33 (2016).
    • 8 De Cremer K, Staes I, Delattin N, Cammue BP, Thevissen K, De Brucker K. Combinatorial drug approaches to tackle Candida albicans biofilms. Expert Rev. Anti Infect. Ther. 13(8), 973–984 (2015).
    • 9 Delattin N, Cammue BP, Thevissen K. Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms. Future Med. Chem. 6(1), 77–90 (2014).
    • 10 Azevedo MM, Teixeira-Santos R, Silva AP et al. The effect of antibacterial and non-antibacterial compounds alone or associated with antifugals upon fungi. Front. Microbiol. 6, 669, eCollection (2015).
    • 11 Candoni A, Caira M, Cesaro S et al. Multicentre surveillance study on feasibility, safety and efficacy of antifungal combination therapy for proven or probable invasive fungal diseases in haematological patients: the SEIFEM real-life combo study. Mycoses 57(6), 342–350 (2014).
    • 12 Delattin N, De Brucker K, De Cremer K, Cammue BPA, Thevissen K. Antimicrobial peptides as a strategy to combat fungal biofilms. Curr. Top. Med. Chem. (2016) (Epub ahead of print).
    • 13 Vriens K, Cools TL, Harvey PJ et al. Synergistic activity of the plant defensin HsAFP1 and caspofungin against Candida albicans biofilms and planktonic cultures. PLoS ONE 10(8), e0132701 (2015).
    • 14 Chang W, Li Y, Zhang L, Cheng A, Liu Y, Lou H. Retigeric acid B enhances the efficacy of azoles combating the virulence and biofilm formation of Candida albicans. Biol. Pharm. Bull. 35(10), 1794–1801 (2012).
    • 15 Lafleur MD, Sun L, Lister I et al. Potentiation of azole antifungals by 2-adamantanamine. Antimicrob. Agents Chemother. 57(8), 3585–3592 (2013).
    • 16 Uppuluri P, Nett J, Heitman J, Andes D. Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob. Agents Chemother. 52(3), 1127–1132 (2008).
    • 17 Bink A, Kucharíková S, Neirinck B et al. The nonsteroidal antiinflammatory drug diclofenac potentiates the in vivo activity of caspofungin against Candida albicans biofilms. J. Infect. Dis. 206(11), 1790–1797 (2012).