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Screening and evaluation of antioxidant activity of some 1,2,4-triazolo[1,5-a]quinazoline derivatives

    Rashad Al-Salahi

    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

    ,
    El-Hassane Anouar

    Department of Chemistry, College of Science & Humanities, Prince Sattam bin Abdulaziz University, 83 Alkharj, Saudi Arabia

    ,
    Mohamed Marzouk

    Department of Chemistry, College of Science & Humanities, Prince Sattam bin Abdulaziz University, 83 Alkharj, Saudi Arabia

    Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo 12622, Egypt

    ,
    Hanan AA Taie

    Plant Biochemistry Department, Division of Agriculture & Biological Researches, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki 12622, Giza, Egypt

    &
    Hatem A Abuelizz

    *Author for correspondence: Tel.: +966114677194; Fax: +966114676220;

    E-mail Address: Habuelizz@ksu.edu.sa

    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

    Published Online:https://doi.org/10.4155/fmc-2017-0224

    Aim: The present study was carried out to assess a new series of triazoloquinazolines 1–40 for their antioxidant activities using 1,1-diphenyl-2-picryl hydrazyl radical scavenging, ferric reduction antioxidant power and reducing power capability assays. Results: All triazoloquinazolines 1–40 exhibited antioxidant activity ranged from weak to moderate and high. The obtained findings revealed that the triazoloquinazolines 30, 36 and 38–40 have superiority among all compounds, demonstrating the highest capacity to deplete 1,1-diphenyl-2-picryl hydrazyl and free radicals, in relation to butylated hydroxyl toluene, as a synthetic antioxidant agent. Conclusion: Chemical modifications together with density functional theory study on the targets supplied us with some valuable clarifications about the required properties needed for the target compounds to be more active against free radicals.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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