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Synthesis and suggestion of a new nanometric gold(III) melatonin drug complex: an interesting model for testicular protection

    Samy M El-Megharbel

    *Author for correspondence:

    E-mail Address: samyelmegharbel@yahoo.com

    Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

    Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

    ,
    Abdulraheem SA Almalki

    Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

    ,
    Reham Z Hamza

    Department of Zoology, Faculty of Science, Zagazig University, Zagazig 44519, Egypt

    Department of Biology, Faculty of Science, Taif University, Saudi Arabia

    ,
    Adil A Gobouri

    Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

    ,
    Abdulrahman A Alhadhrami

    Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

    ,
    Jehan Y Al-Humaidi

    Department of Chemistry, Faculty of Science, Princess Nourah bint Abdulrahman University, Saudi Arabia

    &
    Moamen S Refat

    Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

    Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt

    Published Online:https://doi.org/10.4155/fmc-2018-0008

    Aim: Melatonin (MLT) is a major hormone secreted by the pineal gland. In this study, a gold(III) MLT (Au+3/MLT) complex has been synthesized and investigating its protective effects against testicular damage. Methodology: The structural features of the complex were investigated. For biological assessment, 30 male rats were divided into three groups for 30 days. The first control group, the second received MLT and the third received Au+3/MLT complex. Results: The Au+3/MLT complex was found to be nonelectrolytic with formula (Au[MLT]2[Cl][H2O]). The ligand is monodentate and adopt square-planar geometry. Its particles range in diameter from 35 to 100 nm. MLT affords slight oxidative stress protection. The Au+3/MLT complex significantly decreases TNF-α and IL-1β levels but elevates antioxidant enzyme capacities, reducing lipid peroxidation markers and improving testicular histological structure. Conclusion: The Au+3/MLT complex improves the anti-inflammatory actions of MLT, exhibits potent antioxidant activity and enhances reproductive capacity.

    Graphical abstract

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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