Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice

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References

• 1 Zhu S, Fei S, Li W et al. Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes. Mol. Cell. Biochem. 353(1–2), 305–313 (2011).
  Medline CASGoogle Scholar
• 2 Zhao SP, Chan YC. The role of statins in the prevention and treatment of cardiovascular diseases in diabetes. J. Intern. Med. 3(5), 303–306 (2008).
  Google Scholar
• 3 Wang F, Meng Y. Oxidative stress and Type 2 diabetes. Basic Clinical Med. 28(8), 887–889 (2008).
  Google Scholar
• 4 Jennings PE, Mclaren M, Scott NA et al. The relationship of oxidative stress to thrombotic tendency in Type 1 diabetic patients with retinopathy. Diabetic Med. 8(9), 860 (1991).
  Medline CASGoogle Scholar
• 5 Walsby EJ, Lazenby M, Pepper CJ et al. The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells. Brit. J. Haematol. 161(1), 57–67 (2013).
  Medline CASGoogle Scholar
• 6 Bhansali S, Bhansali A, Walia R et al. Alterations in mitochondrial oxidative stress and mitophagy in subjects with prediabetes and Type 2 diabetes mellitus. Front. Endocrinol. (8), 347 (2017).
  MedlineGoogle Scholar
• 7 Pang JH, Zhou Y, Wang ZJ. Type 2 diabetes and insulin resistance. Hebei Med. 26(4), 292–293 (2004).
  Google Scholar
• 8 Li DF, Yang B, Yang HD et al. The relationship between serum resistin and serum lipids, obesity and insulin resistance in patients with metabolic syndrome. Chinese J. Clinical Med. 12(2), 206–208 (2005).
  Google Scholar
• 9 Schinner S, Scherbaum WA, Bornstein SR, Barthel A. Molecular mechanisms of insulin resistance. Diabet. Med. 22(6), 674–82 (2005).
  Medline CASGoogle Scholar
• 10 Guo S. Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms. J. Endocrinol. 220(2), (2013).
  MedlineGoogle Scholar
• 11 Woodruff ML, Rajala A, Fain GL et al. Effect of knocking down the insulin receptor on mouse rod responses. Sci. Rep. 5 (2015).
  Google Scholar
• 12 Alghamdi F, Guo M, Abdulkhalek S et al. A novel insulin receptor-signaling platform and its link to insulin resistance and Type 2 diabetes. Cell. Signal. 26(6), 1355 (2014).
  Medline CASGoogle Scholar
• 13 Wu Y, Lu H, Yang H et al. Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt-GLUT4, GSK3β and mTOR-S6K1. J. Nutr. Biochem. 34, 126–135 (2016).
  MedlineGoogle Scholar
• 14 Gallagher EJ, Fierz Y, Vijayakumar A et al. Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia. Oncogene 31(27), 3213–22 (2012). •• Demonstrates GLUT4 is an important protein that promotes glucose uptake.
  Medline CASGoogle Scholar
• 15 Chi M, Ye Y, Zhang XD et al. Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway. Drug. Des. Dev. Ther. 8, 255–262 (2014).
  Medline CASGoogle Scholar
• 16 Chinese Materia Medica Editorial Board. In: Chinese Materia Medoca. 6, Shanghai Science and Technology Press, Shanghai, China, 470–472 (1999).
  Google Scholar
• 17 China Pharmacopoeia Committee. In: Pharmacopoeia of People's Republic of China. 1, Chemical Industry Press, Beijing, China, 234 (2015).
  Google Scholar
• 18 Tailor CS, Bahuguna YM, Singh V. Anti-inflammatory activity of ethanolic stem extracts of Rubia cordifolia. Linn. in rats. IJRAP 1(1), 126–130 (2010).
  Google Scholar
• 19 Patel PR, Raval BP, Karanth HA et al. Potent antitumor activity of Rubia cordifolia. Int. J. Phytomed. 2(1), 44–46 (2010).
  CASGoogle Scholar
• 20 Tripathi YB, Shukla S, Sharma M et al. Antioxidant property of Rubia cordifolia extract and its comparison with vitamin E and parabenzoquinone. Phytother. Res. 9(6), 440–443 (2010).
  Google Scholar
• 21 Wang L, Xu Q, Kang WY et al. Influencing factors of antioxidant activity of alizarin. J. Henan Univ. 27(3), 32–34 (2008).
  Google Scholar
• 22 Costa VM, Foti D, Paonessa F, Chiefari E. The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-γ(PPAR-γ) and thiazolidinedione-PPAR-γagonists. Endocr. Relat. Cancer. 15(1), 325–35 (2008). • Provides a basis for the selection of experimental-positive drugs.
  Medline CASGoogle Scholar
• 23 Gao Q, Qin WS, Jia ZH et al. Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med. 76(01), 27–33 (2010).
  Medline CASGoogle Scholar
• 24 Wang M, Zhao R, Wang W et al. Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02. J. Ethnopharmacol. 139(1), 0–293 (2012).
  Google Scholar
• 25 Baron AD. Postprandial hyperglycaemia and alpha-glucosidase inhibitors. Diabetes Res. Clin. Pr. 40(98), 51–55 (1998).
  Google Scholar
• 26 Tang LQ, Wei W, Chen LM, Liu S. Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J. Ethnopharmacol. 108(1), 109–115 (2006).
  Medline CASGoogle Scholar
• 27 Rachmani R, Bar-Dayan Y, Ronen Z, Levi Z, Slavachevsky I, Ravid M. The effect of acarbose on insulin resistance in obese hypertensive subjects with normal glucose tolerance: a randomized controlled study. Diabetes Obes. Meta. 6(1), 63–68 (2010). • Demonstrates the hypoglycemic effect of the positive drug acarbose.
  Google Scholar
• 28 Yazdanparast R, Ardestani A, Jamshidi S. Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters. J. Ethnopharmacol. 112(1), 13–18 (2007).
  MedlineGoogle Scholar
• 29 Nicholas JS. The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance. J. Ethnopharmacol. 277, 206–236 (2018). •• Demonstrates the potential of ashydroxylated anthraquinones to improve insulin resistance.
  Google Scholar
• 30 Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440(7086), 944 (2006). •• Discusses the establishment of insulin resistance model with dexamethasone.
  Medline CASGoogle Scholar
• 31 Xiao YZ. GOD-POD assay for evaluating insulin resistance of 3T3-L1 adipocytes. J. Chongqing Medical Univ. 35(11), 1684–1687 (2010). •• Provides a basis for the determination of glucose uptake by insulin-resistant 3T3-L1 adipocytes.
  Google Scholar
• 32 Tjokroprawiro A. New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer). Acta Med. Indones. 38(3), 160 (2006).
  MedlineGoogle Scholar
• 33 Chiefari E, Nevolo MT, Arcidiacono B et al. HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway. Sci. Rep. 2(1), 251 (2012).
  MedlineGoogle Scholar
• 34 George S, Rochford JJ, Wolfrum C et al. A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304(5675), 1325–1328 (2004).
  Medline CASGoogle Scholar
• 35 Garofalo RS, Orena SJ, Rafidi K et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. 112(2), 197–208 (2003).
  Medline CASGoogle Scholar
• 36 Cho H, Mu J, Kim JK et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292(5522), 1728–1731 (2001). • Indicates that AKT is a key protein of the PI3K/AKT signaling pathway.
  Medline CASGoogle Scholar
• 37 Chiefari E, Paonessa F, Iiritano S et al. The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis. BMC Biol. 7(1), 24 (2009).
  MedlineGoogle Scholar