Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers

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References

• 1. Swerdlow SH, Campo E, Harris NL et al. WHO classification of tumors of haematopoietic and lymphoid tissues (volume 4). In: World Health Organization Classification of Tumour. International Agency for Research on Cancer, Lyon, France (2017). • This book by the World Health Organization provided the currently complete classification of hematological malignancies.
  Google Scholar
• 2. Siveen KS, Uddin S, Mohammad RM. Targeting acute myeloid leukemia stem cell signaling by natural products. Mol. Cancer. 16(1), 1–12 (2017).
  MedlineGoogle Scholar
• 3. Vasekar M, Rizvi S, Liu X, Vrana KE, Zheng H. Novel immunotherapies for hematological malignancies. Curr. Mol. Pharmacol. 9(3), 264–271 (2015).
  Google Scholar
• 4. Grove CS, Vassiliou GS. Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? Dis. Model. Mech. 7(8), 941–951 (2015).
  Google Scholar
• 5. Hojjat-Farsangi M. Novel and emerging targeted-based cancer therapy agents and methods. Tumour Biol. 36(2), 543–556 (2015).
  Medline CASGoogle Scholar
• 6. Villalba M, Lopez-Royuela N, Krzywinska et al. Chemical metabolic inhibitors for the treatment of blood-borne cancers. Anticancer Agents Med. Chem. 14(2), 223–232 (2015).
  Google Scholar
• 7. Chao MW, Lai MJ, Liou JP et al. The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo. J. Hematol. Oncol. 10, 78–82 (2015).
  Google Scholar
• 8. Zhang D, Tang B, Xie X, Xiao YF, Yang SM, Zhang JW. The interplay between DNA repair and autophagy in cancer therapy. Cancer Biol. Ther. 16(7), 1005–1013 (2015).
  Medline CASGoogle Scholar
• 9. Momparler RL. Optimization of cytarabine (ARA-C) therapy for acute myeloid leukemia. Exp. Hematol. Oncol. 2, 20–32 (2015).
  Google Scholar
• 10. Galluzzi L, Vitale I, Aaronson SA et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Diff. 25(3), 486–541 (2018). •• The ultimate guide for cell death and includes morphological, genetic and biochemical descriptions of intrinsic and extrinsic classic apoptosis, as well as immunogenic apoptosis, all mentioned in this paper.
  MedlineGoogle Scholar
• 11. Ahmad N, Mukhtar H. Antioxidants meet molecular targets for cancer prevention and therapeutics. Antioxid. Redox Signal. 19(2), 85–88 (2015).
  Google Scholar
• 12. Singh S, Awasthi M, Pandey VP, Dwivedi U. Natural products as anticancerous therapeutic molecules with special reference to enzymatic targets topoisomerase, COX, LOX and aromatase. Curr. Protein Pept. Sci. 19(3), 238–274 (2018).
  Medline CASGoogle Scholar
• 13. Safarzadeh E, Sandoghchian-Shotorbani S, Baradaran B. Herbal medicine as inducers of apoptosis in cancer treatment. Adv. Pharm. Bull. 4(Suppl. 1), 421–427 (2014).
  MedlineGoogle Scholar
• 14. Gaur R, Pathania AS, Malik FA, Bhakuni RS, Verma RK. Synthesis of a series of novel dihydroartemisinin monomers and dimers containing chalcone as a linker and their anticancer activity. Eur. J. Med. Chem. 122, 232–246 (2016).
  Medline CASGoogle Scholar
• 15. Nkuete AH, Kuete V, Gozzini D et al. Anti-leukemia activity of semi-synthetic phenolic derivatives from Polygonum limbatum Meisn. Chem. Cent. J. 9, 40–46 (2015).
  MedlineGoogle Scholar
• 16. Razmi A, Zarghi A, Arfaee S, Naderi N, Faizi M. Evaluation of anti-nociceptive and anti-inflammatory activities of novel chalcone derivatives. Iran J. Pharm.Res. 12, 153–159 (2014).
  Google Scholar
• 17. Sikander M, Malik S, Yadav D, Biswas S, Katare DP, Jain SK. Cytoprotective activity of a trans-chalcone against hydrogen peroxide induced toxicity in hepatocellular carcinoma (HepG2) cells. Asian Pac. J. Cancer Prev. 12, 2513–2516 (2011).
  MedlineGoogle Scholar
• 18. Slawinska-Brych A, Zdzisinska B, Dmoszynska-Graniczka M et al. Xanthohumol inhibits the extracellular signal-regulated kinase (ERK) signalling pathway and suppresses cell growth of lung adenocarcinoma cells. Toxicology 357, 65–73 (2016).
  MedlineGoogle Scholar
• 19. Rozmer Z, Berki T, Maasz G, Perjesi P. Different effects of two cyclic chalcone analogues on redox status of Jurkat T cells. Toxicol. In Vitro. 28(8), 1359–1365 (2014).
  Medline CASGoogle Scholar
• 20. Leon-Gonzalez AJ, Acero N, Munoz-Mingarro D, Navarro I, Martin-Cordero C. Chalcones as promising lead compounds on cancer therapy. Curr. Med. Chem. 22(30), 3407–3425 (2015).
  Medline CASGoogle Scholar
• 21. Maioral MF, Bodack CDN, Stefanes NM et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochimie 140, 48–57 (2017).
  Medline CASGoogle Scholar
• 22. Mirzaei H, Emami S. Recent advances of cytotoxic chalconoids targeting tubulin polymerization: synthesis and biological activity. Eur. J. Med. Chem. 121, 610–639 (2016).
  Medline CASGoogle Scholar
• 23. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65(1–2), 55–63 (1983).
  Medline CASGoogle Scholar
• 24. Guzy J, Vaskova-Kubalkova J, Rozmer Z et al. Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria. FEBS Lett. 584(3), 567–570 (2010).
  Medline CASGoogle Scholar
• 25. Das M, Manna K. Chalcone scaffold in anticancer armamentarium: a molecular insight. J. Toxicol. 2016, 765–775 (2016).
  Google Scholar
• 26. Letafat B, Shakeri R, Emami S et al. Synthesis and in vitro cytotoxic activity of novel chalcone-like agents. Iran J. Basic Med. Sci. 16(11), 1155–1162 (2013).
  MedlineGoogle Scholar
• 27. Orlikova B, Menezes J, Ji S, Kamat SP, Cavaleiro JA, Diederich M. Methylenedioxy flavonoids: assessment of cytotoxic and anti-cancer potential in human leukemia cells. Eur. J. Med. Chem. 84, 173–180 (2014).
  Medline CASGoogle Scholar
• 28. Lang F, Wojcik B, Rieger MA. Stem cell hierarchy and clonal evolution in acute lymphoblastic leukemia. Stem Cells Int. 2015, 137–164 (2015).
  Google Scholar
• 29. Tomas D, Majeti R. Biology and clinical relevance of acute myeloid leukemia stem cells. Blood 129(12), 1577–1585 (2017). • Describes the importance of cancer stem cells for cancer outcome, as the existence of these cells offers an explanation for chemotherapy resistance and disease relapse.
  MedlineGoogle Scholar
• 30. Li W, Zhang Q, Chen K et al. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC cancer stem cells. BMC Complement. Altern. Med. 19(1), 38–44 (2019).
  MedlineGoogle Scholar
• 31. Korsak J, Goller A, Rzeszotarska A, Pleskacz K. Evaluation of two distinct cryoprotectants for cryopreservation of human red blood cell concentrates. Cryo Lett. 35(1), 15–21 (2014).
  Medline CASGoogle Scholar
• 32. Pagano M, Faggio C. The use of erythrocyte fragility to assess xenobiotic cytotoxicity. Cell Biochem. Funct. 33(6), 351–355 (2015).
  Medline CASGoogle Scholar
• 33. Hung KC, Lin ML, Hsu SW et al. Suppression of Akt-mediated HDAC3 expression and CDK2 T39 phosphorylation by a bichalcone analog contributes to S phase retardation of cancer cells. Eur. J. Pharmacol. 829, 141–150 (2018).
  Medline CASGoogle Scholar
• 34. Gundamaraju R, Vemuri R, Chong WC et al. Interplay between endoplasmic reticular stress and survivin in colonic epithelial cells. Cells 7(10), 15–22 (2018).
  Google Scholar
• 35. Luo Q, Yang D, Qi Q et al. Role of the death receptor and endoplasmic reticulum stress signaling pathways in polyphyllin I-regulated apoptosis of human hepatocellular carcinoma HepG2 cells. Biomed. Res. Int. 25, 524–529 (2019).
  Google Scholar
• 36. Yang Y, Wang G, Wu W et al. Camalexin induces apoptosis via the ROS-ER stress-mitochondrial apoptosis pathway in AML cells. Oxid. Med. Cell Longev. 14, 50–56 (2019). • Described the effects of a natural compound and relates endoplasmic reticulum stress with reactive oxygen species production and apoptosis induction in acute leukemia cells.
  Google Scholar
• 37. McManus MJ, Franklin JL. Dissociation of JNK activation from elevated levels of reactive oxygen species, cytochrome c release, and cell death in NGF-deprived sympathetic neurons. Mol. Neurobiol. 55(1), 382–389 (2018).
  Medline CASGoogle Scholar
• 38. Macchioni L, Petricciuolo M, Davidescu M et al. Palmitate lipotoxicity in enteric glial cells: lipid remodeling and mitochondrial ROS are responsible for cyt c release outside mitochondria. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863(8), 895–908 (2018).
  Medline CASGoogle Scholar
• 39. Jacquemin G, Margiotta D, Kasahara A et al. Granzyme B-induced mitochondrial ROS are required for apoptosis. Cell Death Diff. 22(5), 862–874 (2015).
  Medline CASGoogle Scholar
• 40. Yan Y, Gong Z, Xu Z. Commentary: Lico A causes ER stress and apoptosis via up-regulating miR-144-3p in human lung cancer cell line H292. Biomed. J. 41(6), 391–392 (2018).
  MedlineGoogle Scholar
• 41. Lee JH, Yoon YM, Lee SH. TUDCA-treated mesenchymal stem cells protect against ER stress in the hippocampus of a murine chronic kidney disease model. Int. J. Mol. Sci. 20(3), 31–43 (2019).
  Google Scholar
• 42. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87(1), 99–163 (2017).
  Google Scholar
• 43. Salsman J, Rapkin LM, Margam NN, Duncan R, Bazett-Jones DP, Dellaire G. Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres. Cell Death Dis. 8(3), 2724–2734 (2017).
  Google Scholar
• 44. Wang Q, Ju X, Wang J, Fan Y, Ren M, Zhang H. Immunogenic cell death in anticancer chemotherapy and its impact on clinical studies. Cancer Lett. 1, 438, 17–23 (2018). • Describes the importance of immunogenic cell death in anticancer treatment and its main pathways.
  Google Scholar
• 45. Uscanga-Palomeque AC, Calvillo-Rodríguez KM, Gómez-Morales L et al. CD47 agonist peptide PKHB1 induces immunogenic cell death in T-cell acute lymphoblastic leukemia cells. Cancer Sci. 110(1), 256–268 (2019).
  Medline CASGoogle Scholar
• 46. Laane E, Tamm KP, Buentke E et al. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16(7), 1018–1029 (2019).
  Google Scholar
• 47. Lee SJ, Jeong JH, Lee IH et al. Effect of high-dose vitamin C combined with anti-cancer treatment on breast cancer cells. Anticancer Res. 39(2), 751–758 (2019). • Describes the synergic effect of vitamin C and currently available chemotherapeutics and discusses about the importance of combined therapy in anticancer treatment in order to decrease the adverse effects.
  Medline CASGoogle Scholar
• 48. Kuykendall A, Duployez N, Boissel N, Lancet JE, Welch JS. Acute myeloid leukemia: the good, the bad, and the ugly. Am. Soc. Clin. Oncol. Educ. Book. 38, 555–573 (2018).
  MedlineGoogle Scholar
• 49. Bota M, Fischer-Fodor E, Bochiș OV et al. Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells. Exp. Ther. Med. 17(1), 307–315 (2019).
  Medline CASGoogle Scholar
• 50. Nguyen NT, Nguyen NNT, Tran NTN et al. Synergic activity against MCF-7 breast cancer cell growth of nanocurcumin-encapsulated and cisplatin-complexed nanogels. Molecules 23(12), 46–49 (2018).
  Google Scholar
• 51. Guler Y, Ovey IS. Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels. Bratisl. Lek. Listy 119(11), 692–700 (2018).
  Medline CASGoogle Scholar