Review

*Author for correspondence: Tel.: +91 4712 529 519;

Mycobacterium Research Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India

Division of Infectious Disease, Department of Medicine, & the Ruy V. Lourenço Centre for the Study of Emerging & Re-emerging Pathogens, Rutgers University – New Jersey Medical School, Newark, NJ 07107, USA

^‡Authors contributed equally

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Pau Biak Sang^‡

Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore, 560012, India

Current Address: The University of Texas Health Science Center at Tyler, TX 75708, USA

^‡Authors contributed equally

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Umesh Varshney

**Author for correspondence: Tel.: +91 8022 932 686;

E-mail Address: varshney@iisc.ac.in

Department of Microbiology & Cell Biology, Indian Institute of Science, Bangalore, 560012, India

Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, 560064, India

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Published Online:7 Feb 2020https://doi.org/10.4155/fmc-2019-0267

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Abstract

Infectious diseases continue to be a major cause of human mortality. With the emergence of drug resistance, diseases that were long thought to have been curable by antibiotics are resurging. There is an urgent clinical need for newer antibiotics that target novel cellular pathways to overcome resistance to currently used therapeutics. The base excision repair (BER) pathways of the pathogen restore altered bases and safeguard the genomic integrity of the pathogen from the host's immune response. Although the BER machinery is of paramount importance to the survival of the pathogens, its potential as a drug target is largely unexplored. In this review, we discuss the importance of BER in different pathogenic organisms and the potential of its inhibition with small molecules.

Papers of special note have been highlighted as: • of interest

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Vol. 12, No. 4

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Received 11 September 2019

Accepted 14 November 2019

Published online 7 February 2020

Published in print February 2020

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Acknowledgments

The authors thank the lab members of U Varshney, IISc, and A Kumar, Mycobacterium Research Laboratory, RGCB for their valuable inputs and support during the preparation of the manuscript.

Financial & competing interests disclosure

U Varshney, a J. C. Bose Fellow (Science and Engineering Research Board, Government of India), acknowledges the financial support received from the Department of Biotechnology (DBT), Ministry of Science and Technology; and the Office of the Principal Scientific Advisor, Government of India. The authors acknowledge the support of DBT-IISc partnership programme, University Grants Commission, New Delhi for the Centre of Advanced Studies, and the DST-FIST level II infrastructure support to carry out this work. K Kurthkoti acknowledges the financial support from Ramalingaswami Re-entry fellowship from Department of Biotechnology, Government of India, intramural funds from Rajiv Gandhi Centre for Biotechnology and the extramural fund from Science and Engineering Research Board (CRG/2018/001209), Government of India. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Base excision repair pathways of bacteria: new promise for an old problem

Abstract

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