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One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities

    Nusrat Shafiq

    *Author for correspondence:

    E-mail Address: dr.nusratshafiq@gcwuf.edu.pk

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Nabeel Shahzad

    Department of Chemistry, University of WAH, Wah Cantt, 44700, Pakistan

    ,
    Fatima Rida

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Zaheer Ahmad

    Department of Chemistry, University of WAH, Wah Cantt, 44700, Pakistan

    ,
    Hafiza Ayesha Nazir

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Uzma Arshad

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Gul Zareen

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Naila Attiq

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Shagufta Parveen

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    ,
    Maryam Rashid

    Synthetic & Natural Product Discovery Laboratory, Department of Chemistry, Government College Women’s University Faisalabad, 38000, Pakistan

    &
    Basharat Ali

    Department of Chemistry, Khawaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, Punjab, 64200, Pakistan

    Published Online:https://doi.org/10.4155/fmc-2023-0132

    Background: Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cores were designed and integrated by artificial intelligence. Methods: Novel pyridines were designed and synthesized. Compounds MNS-1MNS-4 were evaluated for their structure and were screened for their in vitro antidiabetic (α-amylase) activity and anticancer (HepG2) activity by methyl thiazolyl tetrazolium assay. Comparative 3D quantitative structure–activity relationship analysis and pharmacophore generation were carried out. Results: The study revealed MNS-1 and MNS-4 as good alternatives to acarbose as antidiabetic agents, and MNS-2 as a more viable, better alternative to doxorubicin in the methyl thiazolyl tetrazolium assay. Conclusion: This combination of studies identifies new and more active analogs of existing FDA-approved drugs for the treatment of diabetes.

    Graphical abstract

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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