Extracting molecular information from African natural products to facilitate unique African-led drug-discovery efforts

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

Bibliography

• 1  World Health Organization. WHO Traditional Medicine Strategy 2002–2005. Geneva, Switzerland (2002).Google Scholar
• 2  Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 Years. J. Nat. Prod.70,461–477 (2007).▪ An exhaustive review of natural products that have served as a source of new-drug entities and novel chemical structures in the 25 years prior to 2007.Crossref, Medline, CAS, Google Scholar
• 3  Nyigo VA, Malebo HM. Drug discovery and developments in developing countries: bottlenecks and way forward. Tanzania Health Res. Bull.7,154–158 (2005).Medline, CAS, Google Scholar
• 4  Trouiller P, Olliaro P, Torreele E, Orbinski J, Liang R, Ford N. Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet359,2188–2194 (2002).Crossref, Medline, Google Scholar
• 5  Coon MJ. Cytochrome P450: nature’s most versatile biological catalyst. Annu. Rev. Pharmacol. Toxicol.45,1–25 (2005).Crossref, Medline, CAS, Google Scholar
• 6  Fura A, Shu Y-Z, Zhu M, Hanson RL, Roongta V, Humphreys WG. Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery. J. Med. Chem.47(18),4339–4350 (2004).▪▪ An excellent account of biotransformation as a source of chemical diversity, and the importance of metabolites in drug discovery.Crossref, Medline, CAS, Google Scholar
• 7  Claus BL, Underwood DJ. Discovery informatics: its evolving role in drug discovery. Drug Discov. Today7(18),957–966 (2002).Crossref, Medline, Google Scholar
• 8  Terstappen GC, Reggiani A. In silico research in drug discovery. Trends Pharmacol. Sci.22(1),23–26 (2001).Crossref, Medline, CAS, Google Scholar
• 9  Bajorath J. Rational drug discovery revisited: interfacing experimental programs with bio- and chemo-informatics. Drug Discov. Today6(19),989–995 (2001).Crossref, Medline, CAS, Google Scholar
• 10  Moitessier N, Englebienne P, Lee D, Lawandi J, Corbeil CR. Towards the development of universal, fast and highly accurate docking/scoring methods: a long way to go. Br. J. Pharmacol.153,S7–S26 (2008).Crossref, Medline, CAS, Google Scholar
• 11  Eddershaw PJ, Beresford AP, Bayliss MK. ADME/PK as part of a rational approach to drug discovery. Drug Discov. Today5(9),409–414 (2000).Crossref, Medline, CAS, Google Scholar
• 12  Yu H, Adedoyin A. ADME–Tox in drug discovery: integration of experimental and computational technologies. Drug Discov. Today8(18),852–861 (2003).▪▪ An overview of predictive (in silico and in vitro) ADME-toxicity, and its role in drug discovery.Crossref, Medline, CAS, Google Scholar
• 101  Queensland Compound Library www.griffith.edu.au/science/queensland-compound-libraryGoogle Scholar
• 102  The University of Arizona’s Natural Products Database http://npd.chem.arizona.eduGoogle Scholar