Review

3D nano- and micro-patterning of biomaterials for controlled drug delivery

Eli J Curry

Department of Biomedical Engineering, The University of Connecticut, CT 06269, USA

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Atta D Henoun

Department of Mechanical Engineering, The University of Connecticut, CT 06269, USA

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Albert N Miller

Department of Mechanical Engineering, The University of Connecticut, CT 06269, USA

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Thanh D Nguyen

*Author for correspondence:

E-mail Address: nguyentd@uconn.edu

Department of Biomedical Engineering, The University of Connecticut, CT 06269, USA

Department of Mechanical Engineering, The University of Connecticut, CT 06269, USA

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Published Online:16 Dec 2016https://doi.org/10.4155/tde-2016-0052

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Abstract

Recently, there has been an emerging interest in controlling 3D structures and designing novel 3D shapes for drug carriers at nano- and micro-scales. Certain 3D shapes and structures of drug particles enable transportation of the drugs to desired areas of the body, allow drugs to target specific cells and tissues, and influence release kinetics. Advanced nano- and micro-manufacturing methods including 3D printing, photolithography-based processes, microfluidics and DNA origami have been developed to generate defined 3D shapes and structures for drug carriers. This paper reviews the importance of 3D structures and shapes on controlled drug delivery, and the current state-of-the-art technologies that allow the creation of novel 3D drug carriers at nano- and micro-scales.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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