We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×

How can microneedles overcome challenges facing transdermal drug delivery?

    Ryan F Donnelly

    *Author for correspondence: Tel.: +44 2890 972 251; Fax: +44 2890 247 794;

    E-mail Address: r.donnelly@qub.ac.uk

    School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

    Published Online:https://doi.org/10.4155/tde-2017-0028
    Free first page

    References

    • 1 Brambilla D, Luciani P, Leroux J. Breakthrough discoveries in drug delivery technologies: the next 30 years. J. Cont. Rel. 190, 9–14 (2014).Crossref, Medline, CASGoogle Scholar
    • 2 Transdermal Market Report. www.micromarketmonitor.com/market-report/transdermal-drug-delivery-systems-reports-8097662643.html.Google Scholar
    • 3 McCrudden MT, Singh TRR, Migalska K, Donnelly RF. Strategies for enhanced peptide and protein delivery. Ther. Deliv. 4, 593–614 (2013).Link, CASGoogle Scholar
    • 4 Biotechnology Drugs Market Report. www.bccresearch.com/market-research/biotechnology.Google Scholar
    • 5 Douroumis D, Fahr A. Drug Delivery Strategies for Poorly Water-Soluble Drugs. Wiley, Oxford, UK (2013).CrossrefGoogle Scholar
    • 6 Drug Devices. www.drug-dev.com.Google Scholar
    • 7 Grand View Research, Inc. www.grandviewresearch.com/industry-analysis/transdermal-drug-delivery-systems-industry.Google Scholar
    • 8 Donnelly RF, Singh TRR, Morrow DIJ, Woolfson AD. Microneedle-Mediated Transdermal and Intradermal Drug Delivery. Wiley, Oxford, UK (2012).CrossrefGoogle Scholar
    • 9 Donnelly RF, Singh TRR, Garland MJ et al. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv. Funct. Mater. 22, 4879–4890 (2012).Crossref, Medline, CASGoogle Scholar
    • 10 Kearney MC, Caffarel-Salvador E, Fallows SJ, McCarthy HO, Donnelly RF. Microneedle-mediated delivery of donepezil: potential for improved treatment options in Alzheimer's disease. Eur. J. Pharm. Biopharm. 103, 43–50 (2016).Crossref, Medline, CASGoogle Scholar
    • 11 Song Y, Herwadkar A, Patel MG, Banga AK. Transdermal delivery of cimetidine across microneedle-treated skin: effect of extent of drug ionization on the permeation. J. Pharm. Sci. doi:10.1016/j.xphs.2017.01.005 (2017) (Epub ahead of print).CrossrefGoogle Scholar
    • 12 McGrath MG, Vrdoljak A, O'Mahony C, Oliveira JC, Moore AC, Crean AM. Determination of parameters for successful spray coating of silicon microneedle arrays. Int. J. Pharm. 415, 140–149 (2011).Crossref, Medline, CASGoogle Scholar
    • 13 Yang HW, Ye L, Guo XD, Yang C, Compans RW, Prausnitz MR. Ebola vaccination using a DNA vaccine coated on PLGA-PLL/γPGA nanoparticles administered using a microneedle patch. Adv. Healthc. Mater. 6(1), (2017). doi:10.1002/adhm.201600750.CrossrefGoogle Scholar
    • 14 Pearton M, Pirri D, Kang SM, Compans RW, Birchall JC. Host responses in human skin after conventional intradermal injection or microneedle administration of virus-like-particle influenza vaccine. Adv. Healthc. Mater. 2, 1401–1410 (2013).Crossref, Medline, CASGoogle Scholar
    • 15 Fernando GJ, Zhang J, Ng HI, Haigh OL, Yukiko SR, Kendall MA. Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8(+) T cell responses. J. Control. Rel. 237, 35–41 (2016).Crossref, Medline, CASGoogle Scholar
    • 16 Janssen Duragesic. www.duragesic.com.Google Scholar
    • 17 Novartis Nicotinell. www.nicotinell.co.uk.Google Scholar
    • 18 Donnelly RF, Moffatt K, Alkilani AZ et al. Hydrogel-forming microneedle arrays can be effectively inserted in skin by self-application: a pilot study centred on pharmacist intervention and a patient information leaflet. Pharm. Res. 31, 1989–1999 (2014).Crossref, Medline, CASGoogle Scholar
    • 19 Norman JJ, Arya JM, McClain MA, Frew PM, Meltzer MI, Prausnitz MR. Microneedle patches: usability and acceptability for self-vaccination against influenza. Vaccine 32, 1856–1862 (2014).Crossref, MedlineGoogle Scholar
    • 20 Vicente-Pérez EM, Quinn HL, McAlister E et al. The use of a pressure-indicating sensor film to provide feedback upon hydrogel-forming microneedle array self-application in vivo. Pharm. Res. 33, 3072–3080 (2016).Crossref, Medline, CASGoogle Scholar
    • 21 Ripolin A, Quinn J, Vicente-Pérez EM, Larrañeta E, Barry JG, Donnelly RF. Successful application of large microneedle patches by human volunteers. Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.02.011 (2017) (Epub ahead of print).Crossref, MedlineGoogle Scholar
    • 22 Sedita J. Microneedles: cost of goods analysis. Proceedings of Microneedles 2016, London (2016).Google Scholar
    • 23 Watkinson AC, Kearney MC, Quinn HL, Courtenay AJ, Donnelly RF. Future of the transdermal drug delivery market: have we barely touched the surface? Expert Opin. Drug Deliv. 13, 523–532 (2016).Crossref, Medline, CASGoogle Scholar
    • 24 Lutton REM, Moore J, Larrañeta E, Ligett S, Woolfson AD, Donnelly RF. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation. Drug Deliv. Transl. Res. 5, 313–331 (2015).Crossref, MedlineGoogle Scholar
    • 25 Liu S, Wu D, Quan YS et al. Improvement of transdermal delivery of exendin-4 using novel tip-loaded microneedle arrays fabricated from hyaluronic acid. Mol. Pharm. 13, 272–279 (2016).Crossref, Medline, CASGoogle Scholar
    • 26 Birchall JC, Clemo R, Anstey A, John DN. Microneedles in clinical practice: an exploratory study into the opinions of healthcare professionals and the public. Pharm. Res. 28, 95–106 (2011).Crossref, Medline, CASGoogle Scholar
    • 27 Vicente-Pérez EM, Larrañeta E, McCrudden MTC et al. Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo. Eur. J. Phar. Biopharm (2017) (In Press).Crossref, MedlineGoogle Scholar