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Lipoproteins for therapeutic delivery: recent advances and future opportunities

    Sangram Raut

    University of North Texas Health Science Center, Fort Worth, TX 76107, USA

    ,
    Jean-Louis Dasseux

    Cerenis Therapeutics Holding SA, Labege, France

    ,
    Nirupama A Sabnis

    University of North Texas Health Science Center, Fort Worth, TX 76107, USA

    ,
    Linda Mooberry

    University of North Texas Health Science Center, Fort Worth, TX 76107, USA

    &
    Andras Lacko

    *Author for correspondence:

    E-mail Address: andras.lacko@unthsc.edu

    University of North Texas Health Science Center, Fort Worth, TX 76107, USA

    Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

    Published Online:https://doi.org/10.4155/tde-2017-0122

    The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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