Special Report

Biocide-conjugated magnetite nanoparticles as an advanced platform for biofilm treatment

Laboratory of Solution Chemistry of Advanced Materials & Technologies, ITMO University, Saint Petersburg, 191002, Russian Federation

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Valeriya Rumyantceva

Laboratory of Solution Chemistry of Advanced Materials & Technologies, ITMO University, Saint Petersburg, 191002, Russian Federation

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Elena Koshel

*Authors for correspondence:

Laboratory of Solution Chemistry of Advanced Materials & Technologies, ITMO University, Saint Petersburg, 191002, Russian Federation

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Vladimir Vinogradov

**Authors for correspondence:

Laboratory of Solution Chemistry of Advanced Materials & Technologies, ITMO University, Saint Petersburg, 191002, Russian Federation

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Published Online:17 Apr 2019https://doi.org/10.4155/tde-2019-0011

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Abstract

Biofilm-related diseases contribute to patient morbidity, increased mortality and represent a considerable economic burden. Despite numerous developments in the field of combating biofilms, the most effective treatment method is still the mechanical removal of biofilms or the replacement of a device overgrown with biofilm. Given that the main challenges are the mechanical stability of biofilms, low penetration of biocides and the persistence of cells with reduced metabolic status in them, a promising direction is the use of magnetically controlled materials for their treatment. Current review discusses recent applications of magnetite-based materials as biocide delivery carriers and effectiveness of these conjugates against biofilms.

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Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 10, No. 4

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History

Received 21 February 2019

Accepted 29 March 2019

Published online 17 April 2019

Published in print April 2019

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Author contributions

V Rumyantceva and V Rumyantceva granted substantial contributions to the conception or design of the work; the acquisition, analysis or interpretation of data for the work. E Koshel helped in drafting the work or revising it critically for important intellectual content; final approval of the version to be published and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. V Vinogradov permitted final approval of the version to be published.

Financial & competing interests disclosure

This work was supported by RFBR (grant number 18-33-20043). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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