Review

Omega-3 fatty acids as adjunctive therapeutics: prospective of nanoparticles in its formulation development

Mohammad Zaki Ahmad

*Author for correspondence:

E-mail Address: zaki.manipal@gmail.com

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia

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Javed Ahmad

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia

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Sobiya Zafar

Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India

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Musarrat Husain Warsi

Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif-Al-Haweiah, 21974, Kingdom of Saudi Arabia

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Basel A Abdel-Wahab

https://orcid.org/0000-0002-5545-6422

Department of Pharmacology, College of Pharmacy, Najran University, Najran, 61441, Kingdom of Saudi Arabia

Department of Pharmacology, College of Medicine, Assiut University, Assiut, 71526, Egypt

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Sohail Akhter

Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India

Le Studium Loire Valley Institute for Advanced Studies, Centre-Val de Loire region, Orleans, 45100, France

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Md Afroze Alam

Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar-Sasaram, Bihar, 821305, India

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Published Online:16 Dec 2019https://doi.org/10.4155/tde-2019-0072

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Abstract

Omega-3 polyunsaturated fatty acids (ω-3-PUFAs) are dietary components that have been extensively recognized for their therapeutic value and have shown diverse therapeutic effects including anti-inflammatory, antiarrhythmic, antithrombotic, immunomodulatory and antineoplastic activities. Most of the ω-3-PUFAs are obtained through diet or supplements because the body does not synthesize them. The high instability of ω-3-PUFAs to oxidative deterioration, lower bioavailability at the target tissues and reduced bioactivity of ω-3-PUFAs is an impediment for achieving their therapeutic potential. The present review provides an overview of potential therapeutic activities of ω-3-PUFAs and different novel technical approaches based on nanotechnology, which have been emphasized to overcome instability problems as well as enhance the bioactivity of ω-3-PUFAs. Future prospects related to this area of research are also provided.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 11, No. 1

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Received 19 September 2019

Accepted 19 November 2019

Published online 16 December 2019

Published in print January 2020

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The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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