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Formulation design and evaluation of aceclofenac nanogel for topical application

    Md. Shoaib Alam

    **Author for correspondence:

    E-mail Address: shoaibpharma@gmail.com

    Research & Development, Jamjoom Pharmaceuticals, Jeddah, Kingdom of Saudi Arabia

    Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi

    ,
    Mohammed S Algahtani

    Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia

    ,
    Javed Ahmad

    Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia

    ,
    Kanchan Kohli

    Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi

    ,
    Sheikh Shafiq-un-Nabi

    Research & Development, Jamjoom Pharmaceuticals, Jeddah, Kingdom of Saudi Arabia

    ,
    Musarrat Husain Warsi

    Department of Pharmaceutics & Industrial Pharmacy, College of Pharmacy, Taif University, Taif-Al-Haweiah, Kingdom of Saudi Arabia

    &
    Mohammad Zaki Ahmad

    *Author for correspondence:

    E-mail Address: zaki.manipal@gmail.com

    Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia

    Published Online:https://doi.org/10.4155/tde-2020-0076

    Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: The composition of optimized NE consist of labrafil along with triacetin as oil, tween 80 and cremophor EL in combination as a surfactant and transcutol HP along with PEG 400 and ethanol as cosurfactant. The droplet size of the NE was 141.1 ± 3.65 nm, with low polydispersity index and negative zeta potential. The aceclofenac–nanoemulgel was developed using carbopol 940 and exhibited excellent permeation in comparison to the marketed sample.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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