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Development of lipid-based microsuspensions for improved ophthalmic delivery of gentamicin sulphate

    Adaeze Linda Onugwu

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Chinazom Precious Agbo

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Chinekwu Sherridan Nwagwu

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Samuel Emeka Uzondu

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Adaeze Chidiebere Echezona

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    John Dike Nwabueze Ogbonna

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Franklin Chimaobi Kenechukwu

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Chukwuebuka Emmanuel Umeyor

    Nanomedicines & Drug Delivery Research Group, Department of Pharmaceutics & Pharmaceutical Technology, Nnamdi Azikiwe University, Agulu, Anambra State, Nigeria

    ,
    Emmanuel Maduabuchi Uronnachi

    Nanomedicines & Drug Delivery Research Group, Department of Pharmaceutics & Pharmaceutical Technology, Nnamdi Azikiwe University, Agulu, Anambra State, Nigeria

    ,
    Paul Achile Akpa

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Mumuni Audu Momoh

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Petra Obioma Nnamani

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    ,
    Christel Charlotte Müller-Goymann

    Institut für Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstr. 1, D-38106, Braunschweig, Germany

    &
    Anthony Amaechi Attama

    *Author for correspondence: Tel.: +234 803 661 8204;

    E-mail Address: anthony.attama@unn.edu.ng

    Drug Delivery & Nanomedicines Research Laboratory, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria

    Institut für Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Mendelssohnstr. 1, D-38106, Braunschweig, Germany

    Published Online:https://doi.org/10.4155/tde-2021-0039

    Aim: Anterior eye segment disorders are treated with eye drops and ointments, which have low ocular bioavailability necessitating the need for improved alternatives. Lipid microsuspension of gentamicin sulphate was developed for the treatment of susceptible eye diseases. Materials & methods: Lipid microsuspensions encapsulating gentamicin sulphate were produced by hot homogenization and evaluated. Ex vivo permeation and ocular irritancy tests were also conducted. Results & conclusion: Stable microsuspensions with high entrapment efficiency and satisfactory osmolarities were obtained. Release studies achieved 49–88% in vitro release at 12 h with sustained permeability of gentamicin compared with conventional gentamicin eye drop (Evril®). No irritation was observed following Draize’s test. The microsuspensions have great potential as ocular delivery system of gentamicin sulphate.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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