Research Article

A low-voltage electro-membrane extraction for quantification of imatinib and sunitinib in biological fluids

*Author for correspondence: Tel.: +98 563 220 2065;

E-mail Address: a_zeraatkar_m@birjand.ac.ir

Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, Iran

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Amir Ehsan Bameri

Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, Iran

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Mohammad Reza Ganjali

Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

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Michal Alexovič

Department of Medical & Clinical Biophysics, Faculty of Medicine, University of P.J. Šafárik in Košice, SK-04011, Košice, Slovakia

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Mehdi Erfani Jazi

Department of Chemistry, Mississippi State University, Mississippi State, Mississippi, MS 39762, USA

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Hadi Tabani

**Author for correspondence: Tel.: +98 212 243 1933;

E-mail Address: h_tabani@sbu.ac.ir

https://orcid.org/0000-0002-5693-4115

Department of Environmental Geology, Research Institute of Applied Sciences (ACECR), Shahid Beheshti University, Tehran, Iran

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Published Online:14 Sep 2021https://doi.org/10.4155/bio-2021-0138

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Abstract

Aim: Hollow-fiber-based supported liquid membrane was modified utilizing nanostructures such as graphite, graphene oxide or nitrogen-doped graphene oxide, for electro-membrane extraction (EME) of imatinib and sunitinib from biological fluids. By applying these conductive nanostructures, a low-voltage EME device (6.0 V) was fabricated. Materials & methods: A response surface methodology through central composite design was used to evaluate and optimize effects of various essential factors that influence on normalized recovery. Results: Optimal extraction conditions were set as, 1-octanol with 0.01 % (w/v) graphene oxide functioning as the supported liquid membrane, an extraction time of 17.0 min, pH of the acceptor and the donor phase of 2.8 and 7.9, respectively. Conclusion: The method was successfully applied to quantify imatinib and sunitinib in biological fluids.

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Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 13, No. 18

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History

Received 19 June 2021

Accepted 31 August 2021

Published online 14 September 2021

Published in print September 2021

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Financial & competing interests disclosure

The University of Birjand, University of Tehran, and the Research Institute of Applied Sciences (ACECR), Shahid Beheshti University are acknowledged for the partial financial support of this project. The partial financial support by the Research Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic (ITMS2014+: 313011V446) and the partial financial support by the Slovak Research and Development Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic (APVV-19-0476), are also acknowledged. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

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