Metabolomics pilot study to identify volatile organic compound markers of childhood asthma in exhaled breath

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References

• 1  British Guideline on the Management of Asthma. Thorax63(Suppl. 4:iv),1–121 (2008).
  MedlineGoogle Scholar
• 2  Amann A, Smith D. Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring. World Scientific Publishing, Singapore (2005).▪ Useful introductory text book.
  Google Scholar
• 3  Van Berkel JJBN, Dallinga JW, Möller GM et al. Development of accurate classification method based on the analysis of volatile organic compounds from human exhaled air. J. Chromatogr. B861(1),101–107 (2008).▪▪ Development and description of data processing workflow for breath analysis.
  Medline CASGoogle Scholar
• 4  Guallar-Hoyas C, Turner MA, Blackburn GJ, Wilson ID, Thomas, CLP. A workflow for the metabolomic/metabonomic investigation of exhaled breath using thermal desorption GC–MS. Bioanalysis4(18),2227–2237 (2012).
  CASGoogle Scholar
• 5  Directive 2004/42/CE of the European Parliament and of the Council on the limitation of emissions of volatile organic compounds due to the use of organic solvents in certain paints and varnishes and vehicle refinishing products and amending Directive 1999/13/EC., L 143. Sect. 87 (2004).
  Google Scholar
• 6  Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo RN. Variation in volatile organic compounds in the breath of normal humans. J. Chromatogr. B Biomed. Sci. Appl.729(1–2),75–88 (1999).
  Medline CASGoogle Scholar
• 7  Barker M, Hengst M, Schmid J et al. Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis. Eur. Respir. J.27(5),929–936 (2006).
  Medline CASGoogle Scholar
• 8  Robroeks CM, van Berkel JJ, Dallinga JW et al. Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr. Res.68(1),75–80 (2010).
  Medline CASGoogle Scholar
• 9  Fens N, Zwinderman AH, van der Schee MP et al. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am. J. Respir. Crit. Care Med.180(11),1076–1082 (2009).
  Medline CASGoogle Scholar
• 10  Dragonieri S, Schot R, Mertens BJ et al. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol.120(4),856–862 (2007).
  MedlineGoogle Scholar
• 11  Dallinga JW, Robroeks CM, van Berkel JJ et al. Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin. Exp. Allergy40(1),68–76 (2010).
  Medline CASGoogle Scholar
• 12  Delfino RJ, Gong H, Linn WS, Hu Y, Pellizzari ED. Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air. J. Expo. Anal. Environ. Epidemiol.13(5),348–363 (2003).
  Medline CASGoogle Scholar
• 13  Ibrahim B, Basanta M, Cadden P et al. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax66(9),804–809 (2011).▪ Study showing asthma biomarkers in adults.
  MedlineGoogle Scholar
• 14  Novak BJ, Blake DR, Meinardi S et al. Exhaled methyl nitrate as a non-invasive marker of hyperglycaemia in type 1 diabetes. Proc. Natl Acad. Sci. USA104(40),15613–15618 (2007).
  Medline CASGoogle Scholar
• 15  Gahleitner F, Guallar-Hoyas C, Blackburn G et al. Towards a metabolomic approach to respiratory disease in childhood: feasibility and acceptability of a novel breath-sampling procedure and initial chemical breath analysis. Thorax64(Suppl. IV),A18 (2009).
  Google Scholar
• 16  Basanta M, Koimtzis T, Singh D, Wilson I, Thomas CLP. An adaptive breath sampler for use with human subjects with an impaired respiratory function. Analyst.132(2),153–163 (2007).
  Medline CASGoogle Scholar
• 17  Hoffmann E de, Stroobant V. Mass Spectrometry: Principles and Applications (3rd Edition). John Wiley & Sons, Ltd, NJ, USA (2007).
  Google Scholar
• 18  Basanta M, Jarvis RM, Xu Y et al. Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst135(2),315–320 (2010).
  Medline CASGoogle Scholar
• 19  Elliott L, Longnecker MP, Kissling GE, London SJ. Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988–1994. Environ. Health Perspect.114(8),1210–1214 (2006).
  Medline CASGoogle Scholar
• 20  Rumchev K, Spickett J, Bulsara M, Phillips M, Stick S. Association of domestic exposure to volatile organic compounds with asthma in young children. Thorax59(9),746–751 (2004).
  Medline CASGoogle Scholar
• 21  Guarneri F, Barbuzza O, Vaccaro M, Galtieri G. Allergic contact dermatitis and asthma caused by limonene in a labourer handling citrus fruits. Contact Dermatitis58(5),315–316 (2008).
  MedlineGoogle Scholar
• 22  Wainman T, Zhang J, Weschler CJ, Lioy PJ. Ozone and limonene in indoor air: a source of submicron particle exposure. Environ. Health Perspect.108(12),1139–1145 (2000).
  Medline CASGoogle Scholar
• 23  Thomas CE, Jackson RL, Ohlweiler DF, Ku G. Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 β release from human blood mononuclear cells. J. Lipid Res.35(3),417–427 (1994).
  Medline CASGoogle Scholar
• 24  Phillips M, Basa-Dalay V. Blais J et al. Point-of-care breath test for biomarkers of active pulmonary tuberculosis. Tuberculosis (Edinb.).92(4) 314–320 (2012).
  MedlineGoogle Scholar