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The critical role of epigallocatechin gallate in regulating mitochondrial metabolism

    Weimei Shi

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    Authors contributed equally

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    ,
    Linfu Li

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Department of Academic Registry, Beijing University of Chinese Medicine, Beijing, 100029 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    Authors contributed equally

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    ,
    Yechun Ding

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    Authors contributed equally

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    ,
    Kai Yang

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    ,
    Zhixi Chen

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    ,
    Xiaona Fan

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    ,
    Shan Jiang

    Department of Academic Registry, Beijing University of Chinese Medicine, Beijing, 100029 PR China

    ,
    Yingjie Guan

    Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI 02903, USA

    ,
    Zhiping Liu

    School of Basic Medicine, Gannan Medical University, Ganzhou 341000, PR China

    ,
    Daohua Xu

    *Author for correspondence:

    E-mail Address: daohuax108@163.com

    Department of Pharmacology, Guangdong Medical University, Dongguan, 523808 PR China

    &
    Longhuo Wu

    **Author for correspondence:

    E-mail Address: longhwu@hotmail.com

    College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China

    Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China

    Published Online:https://doi.org/10.4155/fmc-2017-0204

    Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG. Recent research has gained positive and promising data. This review will discuss the interaction between EGCG and mitochondrion.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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