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Therapeutic charm of quercetin and its derivatives: a review of research and patents

    Ajay Sharma

    Department of Chemistry, Career Point University, Tikker-kharwarian, Hamirpur, Himachal Pradesh 176041, India

    Authors contributed equally

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    ,
    Dharambir Kashyap

    Department of Histopathology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, Punjab 160012, India

    Authors contributed equally

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    , ,
    Hardeep Singh Tuli

    *Author for correspondence:

    E-mail Address: hardeep.biotech@gmail.com

    Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India

    &
    Anil K Sharma

    Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India

    Published Online:https://doi.org/10.4155/ppa-2017-0030

    Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-κBMAPK, PI3K-AKT and mTOR are found to be regulated by quercetin. In addition, several patents have reported recently on quercetin derivatives describing wide therapeutic applications such as anticancer/antiproliferatory, antioxidative/antiaging, antiviral, anti-inflammatory, cardioprotective. Present review emphasizes the chemistry and sources of quercetin followed by description of its broad-spectrum therapeutic potential along with proposed mechanisms of action. Furthermore, this review also highlights the important modifications in the basic chemical structure of quercetin in terms of published patents. Insolubility of the bioactive compounds restricts their medicinal importance which could be overcome by modifications in the chemical structure of so-called derivatives. Most of the patents deal with the modifications in chemical structure of quercetin mainly at hydroxyl groups and C-6 and C-7 positions.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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