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Review

An emerging integration between ionic liquids and nanotechnology: general uses and future prospects in drug delivery

    Tânia Santos de Almeida

    CBIOS-Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal

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    ,
    Ana Júlio

    CBIOS-Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal

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    ,
    Joana Portugal Mota

    CBIOS-Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal

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    ,
    Patrícia Rijo

    CBIOS-Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749–024 Lisboa, Portugal

    iMed.U Lisboa, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649–003 Lisboa, Portugal

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    &
    Catarina Pinto Reis

    *Author for correspondence:

    E-mail Address: catarinapintoreis@gmail.com

    ;

    E-mail Address: catarinareis@ff.ulisboa.pt

    Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749–016 Lisboa, Portugal

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    Published Online:22 May 2017https://doi.org/10.4155/tde-2017-0002

    Abstract

    There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects. This overview on the properties of ILs, NPs and of their combined structures, reveals the recent advances in these areas through a review of pertinent literature. The IL–NP structures present enhanced properties and the subsequent performance upgrade proves to be useful in drug delivery, although much is yet to be done.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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