Omega-3 fatty acids as adjunctive therapeutics: prospective of nanoparticles in its formulation development

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References

• 1. Calder PC. Polyunsaturated fatty acids, inflammation, and immunity. Lipids 36(9), 1007–1024 (2001).
  Medline CASGoogle Scholar
• 2. Covington MB. Omega-3 fatty acids. Am. Fam. Phys. 70(1), 133–140 (2004).
  MedlineGoogle Scholar
• 3. Mori TA, Beilin LJ. Long-chain omega 3 fatty acids, blood lipids and cardiovascular risk reduction. Curr. Opin. Lipidol. 12(1), 11–17 (2001).
  Medline CASGoogle Scholar
• 4. Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 197(1), 12–24 (2008).
  Medline CASGoogle Scholar
• 5. Avijit H, Tripathi SK, Ghosh A. Pharmacology and therapeutic potential of the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fish oils. Indian J. Pharmacol. 31(4), 247–264 (1999).
  Google Scholar
• 6. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J. Am. Coll. Nutr. 21(6), 495–505 (2002).
  Medline CASGoogle Scholar
• 7. Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed. Pharmacother. 56(8), 388–396 (2002).
  Medline CASGoogle Scholar
• 8. Mori TA, Beilin LJ, Burke V, Morris J, Ritchie J. Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 17(2), 279–286 (1997).
  Medline CASGoogle Scholar
• 9. Mori TA, Beilin LJ. Omega-3 fatty acids and inflammation. Curr. Atheroscler. Rep. 6(6), 461–467 (2004).
  MedlineGoogle Scholar
• 10. Connor WE. Importance of n-3 fatty acids in health and disease. Am. J. Clin. Nutr. 71(1 Suppl.), 171S–175S (2000). • Describes the health benefits of omega-3 polyunsaturated fatty acids (ω-3-PUFAs).
  Medline CASGoogle Scholar
• 11. Kagawa Y, Nishizawa M, Suzuki M et al. Eicosapolyenoic acids of serum lipids of Japanese islanders with low incidence of cardiovascular diseases. J. Nutr. Sci. Vitaminol (Tokyo). 28(4), 441–453 (1982).
  Medline CASGoogle Scholar
• 12. Bang HO, Dyerberg J. Lipid metabolism and ischemic heart disease in Greenland Eskimos. In: Adv. Nutr. Draper HH (Ed.). Springer, 1–22 (1980) .
  Google Scholar
• 13. Burr ML, Fehily AM, Gilbert JF et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 2(8666), 757–761 (1989).
  Medline CASGoogle Scholar
• 14. Yokoyama M, Origasa H, Matsuzaki M et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369(9567), 1090–1098 (2007).
  Medline CASGoogle Scholar
• 15. Den Ruijter HM, Berecki G, Opthof T, Verkerk AO, Zock PL, Coronel R. Pro- and antiarrhythmic properties of a diet rich in fish oil. Cardiovasc. Res. 73(2), 316–325 (2007).
  MedlineGoogle Scholar
• 16. London B, Albert C, Anderson ME et al. Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation 116(10), e320–e335 (2007).
  Medline CASGoogle Scholar
• 17. Xiao YF, Morgan JP, Leaf A. Effects of polyunsaturated fatty acids on cardiac voltage-activated K(+) currents in adult ferret cardiomyocytes. Sheng Li Xue Bao 54(4), 271–281 (2002).
  Medline CASGoogle Scholar
• 18. Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am. J. Clin. Nutr. 65(5 Suppl.), 1645S–1654S (1997).
  Medline CASGoogle Scholar
• 19. Howe PR. Dietary fats and hypertension. Focus on fish oil. Ann. NY Acad. Sci. 827, 339–352 (1997). • Describes the importance of ω-3-PUFAs and their role in maintaining blood pressure.
  Medline CASGoogle Scholar
• 20. Morris MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88(2), 523–533 (1993).
  Medline CASGoogle Scholar
• 21. Appel LJ, Miller ER, 3rd, Seidler AJ, Whelton PK. Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Arch. Intern. Med. 153(12), 1429–1438 (1993).
  Medline CASGoogle Scholar
• 22. Sekikawa A, Curb JD, Ueshima H et al. Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese–American, and white men: a cross-sectional study. J. Am. Coll. Cardiol. 52(6), 417–424 (2008).
  Medline CASGoogle Scholar
• 23. Brown AA, Hu FB. Dietary modulation of endothelial function: implications for cardiovascular disease. Am. J. Clin. Nutr. 73(4), 673–686 (2001).
  Medline CASGoogle Scholar
• 24. Leaf A, Weber PC. Cardiovascular effects of n-3 fatty acids. New Engl. J. Med. 318(9), 549–557 (1988).
  Medline CASGoogle Scholar
• 25. Leslie CA, Gonnerman WA, Ullman MD, Hayes KC, Franzblau C, Cathcart ES. Dietary fish oil modulates macrophage fatty acids and decreases arthritis susceptibility in mice. J. Exp. Med. 162(4), 1336–1349 (1985).
  Medline CASGoogle Scholar
• 26. Kremer JM, Lawrence DA, Jubiz W et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum. 33(6), 810–820 (1990).
  Medline CASGoogle Scholar
• 27. Volker D, Fitzgerald P, Major G, Garg M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J. Rheumatol. 27(10), 2343–2346 (2000). • Describes the importance of fish oil in the management of rheumatoid arthritis.
  Medline CASGoogle Scholar
• 28. Feldmann M, Maini RN. The role of cytokines in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford). 38(Suppl 2), 3–7 (1999).
  Medline CASGoogle Scholar
• 29. Cleland LG, French JK, Betts WH, Murphy GA, Elliott MJ. Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. J. Rheumatol. 15(10), 1471–1475 (1988).
  Medline CASGoogle Scholar
• 30. van der Tempel H, Tulleken JE, Limburg PC, Muskiet FA, van Rijswijk MH. Effects of fish oil supplementation in rheumatoid arthritis. Ann. Rheum. Dis. 49(2), 76–80 (1990).
  MedlineGoogle Scholar
• 31. Tulleken JE, Limburg PC, Muskiet FA, van Rijswijk MH. Vitamin E status during dietary fish oil supplementation in rheumatoid arthritis. Arthritis Rheum. 33(9), 1416–1419 (1990).
  Medline CASGoogle Scholar
• 32. Espersen GT, Grunnet N, Lervang HH et al. Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin. Rheumatol. 11(3), 393–395 (1992).
  Medline CASGoogle Scholar
• 33. Sperling RI, Weinblatt M, Robin JL et al. Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. Arthritis Rheum. 30(9), 988–997 (1987).
  Medline CASGoogle Scholar
• 34. Lee YH, Bae SC, Song GG. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Arch. Med. Res. 43(5), 356–362 (2012).
  Medline CASGoogle Scholar
• 35. Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 129(1-2), 210–223 (2007).
  Medline CASGoogle Scholar
• 36. Vilaseca J, Salas A, Guarner F, Rodriguez R, Martinez M, Malagelada JR. Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Gut 31(5), 539–544 (1990).
  Medline CASGoogle Scholar
• 37. Hawthorne AB, Daneshmend TK, Hawkey CJ et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 33(7), 922–928 (1992).
  Medline CASGoogle Scholar
• 38. Hillier K, Jewell R, Dorrell L, Smith CL. Incorporation of fatty acids from fish oil and olive oil into colonic mucosal lipids and effects upon eicosanoid synthesis in inflammatory bowel disease. Gut 32(10), 1151–1155 (1991).
  Medline CASGoogle Scholar
• 39. John S, Luben R, Shrestha SS, Welch A, Khaw KT, Hart AR. Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study. Eur. J. Gastroenterol. Hepatol. 22(5), 602–606 (2010).
  Medline CASGoogle Scholar
• 40. Barbosa DS, Cecchini R, El Kadri MZ, Rodriguez MA, Burini RC, Dichi I. Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. Nutrition 19(10), 837–842 (2003).
  Medline CASGoogle Scholar
• 41. Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin. Exp. Allergy 42(9), 1313–1320 (2012).
  Medline CASGoogle Scholar
• 42. Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol. Int. 64(1), 27–34 (2015).
  Medline CASGoogle Scholar
• 43. Bilal S, Haworth O, Wu L, Weylandt KH, Levy BD, Kang JX. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochim. Biophys. Acta 1812(9), 1164–1169 (2011).
  Medline CASGoogle Scholar
• 44. Morin C, Fortin S, Cantin AM, Rousseau E. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. Am. J. Respir. Cell Mol. Biol. 45(2), 366–375 (2011).
  Medline CASGoogle Scholar
• 45. Morin C, Fortin S, Cantin AM, Rousseau E. MAG-EPA resolves lung inflammation in an allergic model of asthma. Clin. Exp. Allergy 43(9), 1071–1082 (2013).
  Medline CASGoogle Scholar
• 46. Yokoyama A, Hamazaki T, Ohshita A et al. Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. Int. Arch. Allergy Immunol. 123(4), 327–332 (2000).
  Medline CASGoogle Scholar
• 47. Li J, Xun P, Zamora D et al. Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study. Am. J. Clin. Nutr. 97(1), 173–178 (2013).
  Medline CASGoogle Scholar
• 48. Rahman M, Beg S, Ahmad MZ et al. Omega-3 fatty acids as pharmacotherapeutics in psoriasis: current status and scope of nanomedicine in its effective delivery. Curr. Drug Targets 14(6), 708–722 (2013). •• Provides an informative overview on recent nanomedicine advancements of ω-3-PUFAs.
  Medline CASGoogle Scholar
• 49. Bourre JM, Francois M, Youyou A et al. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. Nutr. J. 119(12), 1880–1892 (1989).
  CASGoogle Scholar
• 50. Niu SL, Mitchell DC, Lim SY et al. Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J. Biol. Chem. 279(30), 31098–31104 (2004).
  Medline CASGoogle Scholar
• 51. Nilsson A, Radeborg K, Salo I, Bjorck I. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr. J. 11, 99 (2012).
  Medline CASGoogle Scholar
• 52. Kalmijn S, van Boxtel MP, Ocke M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology 62(2), 275–280 (2004).
  Medline CASGoogle Scholar
• 53. Hashimoto M, Hossain S, Shimada T, Shido O. Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. Clin. Exp. Pharmacol. Physiol. 33(10), 934–939 (2006).
  Medline CASGoogle Scholar
• 54. Green KN, Martinez-Coria H, Khashwji H et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 27(16), 4385–4395 (2007).
  Medline CASGoogle Scholar
• 55. Ma QL, Teter B, Ubeda OJ et al. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer’s disease (AD): relevance to AD prevention. J. Neurosci. 27(52), 14299–14307 (2007).
  Medline CASGoogle Scholar
• 56. D’Eliseo D, Velotti F. Omega-3 Fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy. J. Clin. Med. 5(2), pii: E15 (2016).
  MedlineGoogle Scholar
• 57. Berquin IM, Edwards IJ, Chen YQ. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 269(2), 363–377 (2008).
  Medline CASGoogle Scholar
• 58. Biondo PD, Brindley DN, Sawyer MB, Field CJ. The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy. J. Nutr. Biochem. 19(12), 787–796 (2008).
  Medline CASGoogle Scholar
• 59. de Aguiar Pastore Silva J, Emilia de Souza Fabre M, Waitzberg DL. Omega-3 supplements for patients in chemotherapy and/or radiotherapy: a systematic review. Clin. Nutr. 34(3), 359–366 (2015).
  MedlineGoogle Scholar
• 60. Wang J, Luo T, Li S, Zhao J. The powerful applications of polyunsaturated fatty acids in improving the therapeutic efficacy of anticancer drugs. Expert Opin. Drug Deliv. 9(1), 1–7 (2012).
  MedlineGoogle Scholar
• 61. Yang T, Fang S, Zhang HX et al. N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. J. Nutr. Biochem. 24(5), 744–753 (2013).
  Medline CASGoogle Scholar
• 62. Merendino N, Costantini L, Manzi L, Molinari R, D’Eliseo D, Velotti F. Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed. Res. Int. 2013, 310186 (2013). •• Explains the role of ω-3-PUFAs as a potential therapeutics adjuvant in cancer treatment.
  MedlineGoogle Scholar
• 63. Siddiqui RA, Harvey K, Stillwell W. Anticancer properties of oxidation products of docosahexaenoic acid. Chem. Phys. Lipids 153(1), 47–56 (2008).
  Medline CASGoogle Scholar
• 64. Siddiqui RA, Harvey KA, Xu Z, Bammerlin EM, Walker C, Altenburg JD. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. BioFactors 37(6), 399–412 (2011).
  Medline CASGoogle Scholar
• 65. Hawkins RA, Sangster K, Arends MJ. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J. Pathol. 185(1), 61–70 (1998).
  Medline CASGoogle Scholar
• 66. Rose DP, Connolly JM. Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture. Cancer Res. 50(22), 7139–7144 (1990).
  Medline CASGoogle Scholar
• 67. Heimli H, Giske C, Naderi S, Drevon CA, Hollung K. Eicosapentaenoic acid promotes apoptosis in Ramos cells via activation of caspase-3 and -9. Lipids 37(8), 797–802 (2002).
  Medline CASGoogle Scholar
• 68. Rose DP, Connolly JM. Dietary fat and breast cancer metastasis by human tumor xenografts. Breast Cancer Res. Treat. 46(2-3), 225–237 (1997).
  Medline CASGoogle Scholar
• 69. Karmali RA, Reichel P, Cohen LA et al. The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor. Anticancer Res. 7(6), 1173–1179 (1987).
  Medline CASGoogle Scholar
• 70. Rose DP, Cohen LA. Effects of dietary menhaden oil and retinyl acetate on the growth of DU 145 human prostatic adenocarcinoma cells transplanted into athymic nude mice. Carcinogenesi. 9(4), 603–605 (1988).
  Medline CASGoogle Scholar
• 71. Kobayashi N, Barnard RJ, Henning SM et al. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin. Cancer Res. 12(15), 4662–4670 (2006).
  Medline CASGoogle Scholar
• 72. Funahashi H, Satake M, Hasan S et al. Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas 36(4), 353–362 (2008).
  Medline CASGoogle Scholar
• 73. Jacobsen C. Omega-3s in food emulsions: overview and case studies. Agro Food Ind. Hi-Tech. 19(5), 9–13 (2008).
  CASGoogle Scholar
• 74. Taneja A, Zhu X. The trouble with omega-3 oils. Funct. Ingred. 26–28 (2006).
  Google Scholar
• 75. Taneja A, Singh H. Challenges for the delivery of long-chain n-3 fatty acids in functional foods. Annu. Rev. Food Sci. Technol. 3, 105–123 (2012).
  Medline CASGoogle Scholar
• 76. Ries D. Studies on the Antioxidant Activity of Milk Proteins in Model Oil-in-Water Emulsions: A Thesis Presented in Partial Fulfilment of the Requirements for the Degree of Doctor of Philosophy in Food Technology, Riddet Institute, Massey University, Palmerston North, New Zealand (PhD dissertation). Massey University (2009).
  Google Scholar
• 77. Shahidi F, Han XQ. Encapsulation of food ingredients. Crit. Rev. Food Sci. Nutr. 33(6), 501–547 (1993).
  Medline CASGoogle Scholar
• 78. Garg M, Wood L, Singh H, Moughan P. Means of delivering recommended levels of long chain n‐3 polyunsaturated fatty acids in human diets. J. Food Sci. 71(5), R66–R71 (2006).
  CASGoogle Scholar
• 79. Deshpande D, Janero DR, Amiji M. Engineering of an omega-3 polyunsaturated fatty acid-containing nanoemulsion system for combination C6-ceramide and 17beta-estradiol delivery and bioactivity in human vascular endothelial and smooth muscle cells. Nanomedicine 9(7), 885–894 (2013). •• Describes the nanoencapsulation technique (nanoemulsion) and enhanced bioactivity of ω-3-PUFAs.
  Medline CASGoogle Scholar
• 80. Shinde RL, Devarajan PV. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv. 24(1), 152–161 (2017).
  Medline CASGoogle Scholar
• 81. Deshpande D, Kethireddy S, Janero DR, Amiji MM. Therapeutic efficacy of an omega-3-fatty acid-containing 17-beta estradiol nano-delivery system against experimental atherosclerosis. PLoS One 11(2), e0147337 (2016).
  MedlineGoogle Scholar
• 82. Garrastazu Pereira G, Rawling T, Pozzoli M et al. Nanoemulsion-enabled oral delivery of novel anticancer omega-3 fatty acid derivatives. Nanomaterials (Basel) 8(10), (2018).
  Google Scholar
• 83. Ahmad G, Gattacecca F, El Sadda R et al. Biodistribution and pharmacokinetic evaluations of a novel taxoid DHA-SBT-1214 in an oil-in-water nanoemulsion formulation in naive and tumor-bearing mice. Pharm. Res. 35(4), 91 (2018).
  MedlineGoogle Scholar
• 84. Ahmad G, El Sadda R, Botchkina G, Ojima I, Egan J, Amiji M. Nanoemulsion formulation of a novel taxoid DHA-SBT-1214 inhibits prostate cancer stem cell-induced tumor growth. Cancer Lett. 406, 71–80 (2017).
  Medline CASGoogle Scholar
• 85. Ou W, Mulik RS, Anwar A, McDonald JG, He X, Corbin IR. Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma. Free Radic. Biol. Med. 112, 597–607 (2017).
  Medline CASGoogle Scholar
• 86. Reynolds L, Mulik RS, Wen X, Dilip A, Corbin IR. Low-density lipoprotein-mediated delivery of docosahexaenoic acid selectively kills murine liver cancer cells. Nanomedicine 14), 2123–2141 (2014).
  MedlineGoogle Scholar
• 87. Wen X, Reynolds L, Mulik RS et al. Hepatic arterial infusion of low-density lipoprotein docosahexaenoic acid nanoparticles selectively disrupts redox balance in hepatoma cells and reduces growth of orthotopic liver tumors in rats. Gastroenterology 150(2), 488–498 (2016).
  Medline CASGoogle Scholar
• 88. Moss LR, Mulik RS, Van Treuren T, Kim SY, Corbin IR. Investigation into the distinct subcellular effects of docosahexaenoic acid loaded low-density lipoprotein nanoparticles in normal and malignant murine liver cells. Biochim. Biophys. Acta 1860(11 Pt A), 2363–2376 (2016).
  Medline CASGoogle Scholar
• 89. Zu Y, Hu Y, Yu X, Jiang S. Docetaxel-loaded bovine serum albumin nanoparticles conjugated docosahexaenoic acid for inhibiting lung cancer metastasis to bone. Anticancer Agents Med. Chem. 17(4), 542–551 (2017).
  Medline CASGoogle Scholar
• 90. Hussein J, Rasheed W, Ramzy T et al. Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes. Hum. Exp. Toxicol. 38(8), 962–973 (2019).
  Medline CASGoogle Scholar
• 91. Guerzoni LP, Nicolas V, Angelova A. In vitro modulation of TrkB receptor signaling upon sequential delivery of curcumin-DHA loaded carriers towards promoting neuronal survival. Pharm. Res. 34(2), 492–505 (2017).
  Medline CASGoogle Scholar
• 92. Roy J, Oliveira LT, Oger C et al. Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation. J. Exp. Clin. Cancer Res. 34, 155 (2015).
  MedlineGoogle Scholar
• 93. Khan AA, Alanazi AM, Jabeen M, Hassan I, Bhat MA. Targeted nano-delivery of novel omega-3 conjugate against hepatocellular carcinoma: Regulating COX-2/bcl-2 expression in an animal model. Biomed. Pharmacother. 81, 394–401 (2016).
  MedlineGoogle Scholar
• 94. Alaarg A, Jordan NY, Verhoef JJ, Metselaar JM, Storm G, Kok RJ. Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment. Int. J. Nanomedicine 11, 5027–5040 (2016).
  Medline CASGoogle Scholar
• 95. Skibinski CG, Das A, Chen KM et al. A novel biologically active acid stable liposomal formulation of docosahexaenoic acid in human breast cancer cell lines. Chem. Biol. Interact. 252, 1–8 (2016).
  Medline CASGoogle Scholar
• 96. Mussi SV, Silva RC, Oliveira MC, Lucci CM, Azevedo RB, Ferreira LA. New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. Eur. J. Pharm. Sci. 48(1-2), 282–290 (2013).
  Medline CASGoogle Scholar
• 97. Jenski LJ, Zerouga M, Stillwell W. Omega-3 fatty acid-containing liposomes in cancer therapy. Proc. Soc. Exp. Biol. Med. 210(3), 227–233 (1995).
  Medline CASGoogle Scholar
• 98. Calle D, Negri V, Ballesteros P, Cerdan S. Magnetoliposomes loaded with poly-unsaturated fatty acids as novel theranostic anti-inflammatory formulations. Theranostics 5(5), 489–503 (2015). •• Explains the role of ω-3-PUFAs magnetoliposome for anti-inflammatory activity.
  Medline CASGoogle Scholar
• 99. Cassano R, Mellace S, Marrelli M, Conforti F, Trombino S. alpha-Tocopheryl linolenate solid lipid nanoparticles for the encapsulation, protection, and release of the omega-3 polyunsaturated fatty acid: in vitro anti-melanoma activity evaluation. Colloids Surf. B Biointerfaces 151, 128–133 (2017).
  Medline CASGoogle Scholar
• 100. Serini S, Cassano R, Corsetto PA, Rizzo AM, Calviello G, Trombino S. Omega-3 PUFA loaded in resveratrol-based solid lipid nanoparticles: physicochemical properties and antineoplastic activities in human colorectal cancer cells in vitro. Int. J. Mol. Sci. 19(2), E586 (2018).
  MedlineGoogle Scholar
• 101. Valdes SA, Alzhrani RF, Rodriguez A, Lansakara PD, Thakkar SG, Cui Z. A solid lipid nanoparticle formulation of 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine with increased solubility, stability, and antitumor activity. Int. J. Pharm. 570, 118609 (2019).
  Medline CASGoogle Scholar
• 102. Sreedhar R, Kumar VS, Bhaskaran Pillai AK, Mangalathillam S. Omega-3 fatty acid based nanolipid formulation of atorvastatin for treating hyperlipidemia. Adv. Pharm. Bull. 9(2), 271–280 (2019).
  Medline CASGoogle Scholar
• 103. Khan S, Ganguli M, Aditya A, Khan S, Baboota S, Ali J. Improved in vivo performance and immunomodulatory effect of novel Omega-3 fatty acid based Tacrolimus nanostructured lipid carrier. J. Drug Deliv. Sci. Technol. 52, 138–149 (2019).
  CASGoogle Scholar
• 104. Rakotoarisoa M, Angelov B, Garamus VM, Angelova A. Curcumin-and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H2O2-induced oxidative stress in differentiated human SH-SY5Y cells. ACS Omega. 4(2), 3061–3073 (2019).
  CASGoogle Scholar
• 105. Kaushik P, Dowling K, Barrow CJ, Adhikari B. Microencapsulation of omega-3 fatty acids: a review of microencapsulation and characterization methods. J. Funct. Foods. 19, 868–881 (2015).
  CASGoogle Scholar
• 106. Arshady R. Microcapsules for food. J. Microencapsul. 10(4), 413–435 (1993).
  Medline CASGoogle Scholar
• 107. Risch SJ. Encapsulation: overview of uses and techniques. In: Encapsulation and Controlled Release of Food Ingredients. Risch JSGary A (Eds). Reineccius publisher: American Chemical Society, Washington DC, USA (1995).
  Google Scholar
• 108. Gharsallaoui A, Roudaut G, Chambin O, Voilley A, Saurel R. Applications of spray-drying in microencapsulation of food ingredients: An overview. Food Res. Int. 40(9), 1107–1121 (2007).
  CASGoogle Scholar
• 109. Nedovic V, Kalusevic A, Manojlovic V, Levic S, Bugarski B. An overview of encapsulation technologies for food applications. Procedia Food Sci. 1, 1806–1815 (2011).
  CASGoogle Scholar
• 110. Carneiro HC, Tonon RV, Grosso CR, Hubinger MD. Encapsulation efficiency and oxidative stability of flaxseed oil microencapsulated by spray drying using different combinations of wall materials. J. Food Eng. 115(4), 443–451 (2013).
  CASGoogle Scholar
• 111. Jimenez M, Garcia H, Beristain C. Spray‐dried encapsulation of conjugated linoleic acid (CLA) with polymeric matrices. J. Sci. Food Agric. 86(14), 2431–2437 (2006).
  CASGoogle Scholar
• 112. Jafari SM, Assadpoor E, Bhandari B, He Y. Nano-particle encapsulation of fish oil by spray drying. Food Res. Int. 41(2), 172–183 (2008).
  CASGoogle Scholar
• 113. Tonon RV, Grosso CR, Hubinger MD. Influence of emulsion composition and inlet air temperature on the microencapsulation of flaxseed oil by spray drying. Food Res. Int. 44(1), 282–289 (2011).
  CASGoogle Scholar
• 114. Depypere F, Dewettinck K, Ronsse F, Pieters J. Food powder microencapsulation: principles, problems and opportunities. Appl. Biotechnol. Food Sci. Policy 1(2), 75–94 (2003).
  CASGoogle Scholar
• 115. Ahmad MZ, Akhter S, Mohsin N et al. Transformation of curcumin from food additive to multifunctional medicine: nanotechnology bridging the gap. Curr. Drug Discov. Technol. 11(3), 197–213 (2014).
  Medline CASGoogle Scholar
• 116. Ahmad MZ, Alkahtani SA, Akhter S et al. Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art. J. Drug Target 24(4), 273–293 (2016). • Detailed review on the application of nanotechnology in the field of therapeutic delivery of curcumin.
  Medline CASGoogle Scholar
• 117. Gulotta A, Saberi AH, Nicoli MC, McClements DJ. Nanoemulsion-based delivery systems for polyunsaturated (omega-3) oils: formation using a spontaneous emulsification method. J. Agric. Food Chem. 62(7), 1720–1725 (2014).
  Medline CASGoogle Scholar
• 118. Walker R, Decker EA, McClements DJ. Development of food-grade nanoemulsions and emulsions for delivery of omega-3 fatty acids: opportunities and obstacles in the food industry. Food Funct. 6(1), 42–55 (2015).
  MedlineGoogle Scholar
• 119. McClements DJ, Rao J. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit. Rev. Food Sci. Nutr. 51(4), 285–330 (2011).
  Medline CASGoogle Scholar
• 120. McClements DJ. Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter. 7(6), 2297–2316 (2011).
  CASGoogle Scholar
• 121. Forgiarini A, Esquena J, Gonzalez C, Solans C. Formation of nano-emulsions by low-energy emulsification methods at constant temperature. Langmuir 17(7), 2076–2083 (2001).
  CASGoogle Scholar
• 122. Anton N, Benoit JP, Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates-a review. J. Control. Rel. 128(3), 185–199 (2008).
  Medline CASGoogle Scholar
• 123. Kumar Dey T, Ghosh S, Ghosh M, Koley H, Dhar P. Comparative study of gastrointestinal absorption of EPA & DHA rich fish oil from nano and conventional emulsion formulation in rats. Food Res. Int. 49(1), 72–79 (2012).
  Google Scholar
• 124. Belhaj N, Arab-Tehrany E, Linder M. Oxidative kinetics of salmon oil in bulk and in nanoemulsion stabilized by marine lecithin. Process. Biochem. 45(2), 187–195 (2010).
  CASGoogle Scholar
• 125. Esquerdo VM, Dotto GL, Pinto LAA. Preparation of nanoemulsions containing unsaturated fatty acid concentrate-chitosan capsules. J. Colloid Interface Sci. 445, 137–142 (2015).
  Medline CASGoogle Scholar
• 126. Uluata S, McClements DJ, Decker EA. Physical stability, autoxidation, and photosensitized oxidation of omega-3 oils in nanoemulsions prepared with natural and synthetic surfactants. J. Agric. Food Chem. 63(42), 9333–9340 (2015).
  Medline CASGoogle Scholar
• 127. Kumar D, Ali J, Baboota S. Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies. Drug Deliv. 23(2), 591–600 (2016).
  Medline CASGoogle Scholar
• 128. Mishra V, Bansal KK, Verma A et al. Solid lipid nanoparticles: emerging colloidal nano drug delivery systems. Pharmaceutics. 10(4), (2018).
  Google Scholar
• 129. Manjunath K, Reddy JS, Venkateswarlu V. Solid lipid nanoparticles as drug delivery systems. Methods Find Exp Clin Pharmacol. 27(2), 127–144 (2005).
  Medline CASGoogle Scholar
• 130. Tamjidi F, Shahedi M, Varshosaz J, Nasirpour A. Nanostructured lipid carriers (NLC): a potential delivery system for bioactive food molecules. Innov. Food Sci. Emerg. Technol. 19, 29–43 (2013).
  CASGoogle Scholar
• 131. Muller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int. J. Pharm. 242(1-2), 121–128 (2002).
  Medline CASGoogle Scholar
• 132. Shahparast Y, Eskandani M, Rajaei A, Yari Khosroushahi A. Preparation, physicochemical characterization and oxidative stability of omega-3 fish oil/alpha-tocopherol-co-loaded nanostructured lipidic carriers. Adv. Pharm. Bull. 9(3), 393–400 (2019).
  Medline CASGoogle Scholar
• 133. Luzzati V, Husson F. The structure of the liquid–crystalline phasis of lipid–water systems. J. Cell. Biol. 12, 207–219 (1962).
  Medline CASGoogle Scholar
• 134. Garg G, Saraf S, Saraf S. Cubosomes: an overview. Biol. Pharm. Bull 30(2), 350–353 (2007).
  Medline CASGoogle Scholar
• 135. Borné J, Nylander T, Khan A. Effect of lipase on monoolein-based cubic phase dispersion (cubosomes) and vesicles. J. Phys. Chem. B. 106(40), 10492–10500 (2002). •• Explains the formulation and evaluation of ω-3-PUFAs loaded cubosome.
  CASGoogle Scholar
• 136. Drummond CJ, Fong C. Surfactant self-assembly objects as novel drug delivery vehicles. Curr. Opin. Colloid Interface Sci. 4(6), 449–456 (1999).
  CASGoogle Scholar
• 137. Anderson DM, Wennerstroem H. Self-diffusion in bicontinuous cubic phases, L3 phases, and microemulsions. J. Phys. Chem. 94(24), 8683–8694 (1990).
  CASGoogle Scholar
• 138. Spicer PT. Progress in liquid crystalline dispersions: cubosomes. Curr. Opin. Colloid Interface Sci. 10(5-6), 274–279 (2005).
  CASGoogle Scholar
• 139. Angelova A, Angelov B, Garamus VM, Drechsler M. A vesicle-to-sponge transition via the proliferation of membrane-linking pores in ω-3 polyunsaturated fatty acid-containing lipid assemblies. J. Mol. 279, 518–523 (2019).
  CASGoogle Scholar
• 140. Angelova A, Drechsler M, Garamus VM, Angelov B. Liquid crystalline nanostructures as pegylated reservoirs of omega-3 polyunsaturated fatty acids: Structural insights toward delivery formulations against neurodegenerative disorders. ACS Omega. 3(3), 3235–3247 (2018).
  Medline CASGoogle Scholar