Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery

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References

• 1. Müller RH, Mäder KGS. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur. J. Pharm. Biopharm. 50(1), 161–177 (2000).
  Medline CASGoogle Scholar
• 2. Fonseca-Santos B, Chorilli M, Palmira Daflon Gremião M. Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease. Int. J. Nanomedicine 4981 (2015). www.dovepress.com/nanotechnology-based-drug-delivery-systems-for-the-treatment-of-alzhei-peer-reviewed-article-IJN
  MedlineGoogle Scholar
• 3. Mehnert WMK. Solid lipid nanoparticles production, characterization and applications. Adv. Drug Deliv. Rev. 47(2–3), 165–196 (2001).
  Medline CASGoogle Scholar
• 4. Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Adv. Pharm. Bull. 5(3), 305–313 (2015).
  Medline CASGoogle Scholar
• 5. Leong TSH, Wooster TJ, Kentish SE, Ashokkumar M. Minimising oil droplet size using ultrasonic emulsification. Ultrason. Sonochem. 16(6), 721–727 (2009).
  Medline CASGoogle Scholar
• 6. Tadros T, Izquierdo P, Esquena J, Solans C. Formation and stability of nano-emulsions. Adv. Colloid Interface Sci. 108–109, 303–318 (2004).
  Medline CASGoogle Scholar
• 7. Shinoda K, Saito H. The stability of O/W type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT-method. J. Colloid Interface Sci. 30(2), 258–263 (1969).
  CASGoogle Scholar
• 8. Wadle A, Förster T, von Rybinski W. Influence of the microemulsion phase structure on the phase inversion temperature emulsification of polar oils. Colloids Surfaces A Physicochem. Eng. Asp. 76, 51–57 (1993).
  CASGoogle Scholar
• 9. Zhang L, Hayes DG, Chen G, Zhong Q. Transparent dispersions of milk-fat-based nanostructured lipid carriers for delivery of β-carotene. J. Agric. Food Chem. 61(39), 9435–9443 (2013).
  Medline CASGoogle Scholar
• 10. Khan MZI, Raušl D, Zanoški R et al. Classification of loratadine based on the biopharmaceutics drug classification concept and possible in vitro–in vivo correlation. Biol. Pharm. Bull. 27(10), 1630–1635 (2004).
  Medline CASGoogle Scholar
• 11. Kemken J, Ziegler A, Müller BW. Influence of supersaturation on the pharmacodynamic effect of bupranolol after dermal administration using microemulsions as vehicle. Pharm. Res. An Off. J. Am. Assoc. Pharm. Sci. 9(4), 554–558 (1992).
  CASGoogle Scholar
• 12. Wissing S. Cosmetic applications for solid lipid nanoparticles (SLN). Int. J. Pharm. 254(1), 65–68 (2003).
  Medline CASGoogle Scholar
• 13. Waters LJ, Jesney H, Molinari M, Shahzad Y. Quantification of the adsorption of benzoates on poly(dimethylsiloxane) membrane. Eur. Polym. J. 118, 286–289 (2019).
  CASGoogle Scholar
• 14. Kiefer J, Frank K, Zehentbauer F, Schuchmann H. Infrared spectroscopy of bilberry extract water-in-oil emulsions: sensing the water-oil interface. Biosensors 6(2), 13 (2016). • Describes the use of Fourier-transform infrared spectroscopy as a technique to investigate the stability of emulsions.
  MedlineGoogle Scholar
• 15. Sarheed O, Shouqair D, Ramesh KVRNS et al. Formation of stable nanoemulsions by ultrasound-assisted two-step emulsification process for topical drug delivery: effect of oil phase composition and surfactant concentration and loratadine as ripening inhibitor. Int. J. Pharm. 576, (2020).
  MedlineGoogle Scholar
• 16. Patel K, Padhye S, Nagarsenker M. Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design. AAPS PharmSciTech 13(1), 125–133 (2012).
  MedlineGoogle Scholar
• 17. Cirri M, Maestrini L, Maestrelli F et al. Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy. Drug Deliv. 25(1), 1910–1921 (2018).
  Medline CASGoogle Scholar
• 18. Kelidari HR, Saeedi M, Akbari J et al. Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. Colloids Surfaces B Biointerfaces 128, 473–479 (2015).
  Medline CASGoogle Scholar
• 19. Montenegro L, Turnaturi R, Parenti C, Pasquinucci L. In vitro evaluation of sunscreen safety: effects of the vehicle and repeated applications on skin permeation from topical formulations. Pharmaceutics 10(1), 27 (2018).
  Google Scholar
• 20. Montenegro L, Carbone C, Puglisi G. Vehicle effects on in vitro release and skin permeation of octylmethoxycinnamate from microemulsions. Int. J. Pharm. 405(1–2), 162–168 (2011).
  Medline CASGoogle Scholar
• 21. Ramulu G. A new validated liquid chromatographic method for the determination of loratadine and its impurities. Sci. Pharm. 79(2), 277–291 (2011).
  Medline CASGoogle Scholar
• 22. Chattopadhyay N, Zastre J, Wong H-L, Wu XY, Bendayan R. Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line. Pharm. Res. 25(10), 2262–2271 (2008).
  Medline CASGoogle Scholar
• 23. Kentish S, Wooster TJ, Ashokkumar M, Balachandran S, Mawson R, Simons L. The use of ultrasonics for nanoemulsion preparation. Innov. Food Sci. Emerg. Technol. 9(2), 170–175 (2008).
  CASGoogle Scholar
• 24. Aserin A, Garti N. Microemulsions for solubilization and delivery of nutraceuticals and drugs. In: Microencapsulation Methods and Industrial Applications. Benita S (Ed.). Taylor Francis, FL, USA, 345–428 (2005).
  Google Scholar
• 25. Rao J, McClements DJ. Lemon oil solubilization in mixed surfactant solutions: rationalizing microemulsion & nanoemulsion formation. Food Hydrocoll. 26(1), 268–276 (2012).
  CASGoogle Scholar
• 26. McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 8(6), 1719–1729 (2012).
  CASGoogle Scholar
• 27. An Y, Yan X, Li B, Li Y. Microencapsulation of capsanthin by self-emulsifying nanoemulsions and stability evaluation. Eur. Food Res. Technol. 239(6), 1077–1085 (2014).
  CASGoogle Scholar
• 28. Izquierdo P, Esquena J, Tadros TF et al. Formation and stability of nano-emulsions prepared using the phase inversion temperature method. Langmuir 18(1), 26–30 (2002).
  CASGoogle Scholar
• 29. Ee SL, Duan X, Liew J, Nguyen QD. Droplet size and stability of nano-emulsions produced by the temperature phase inversion method. Chem. Eng. J. 140(1–3), 626–631 (2008).
  CASGoogle Scholar
• 30. Jose S, Anju SS, Cinu TA, Aleykutty NA, Thomas S, Souto EB. In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery. Int. J. Pharm. 474(1–2), 6–13 (2014).
  Medline CASGoogle Scholar
• 31. Rigon RB, Gonçalez ML, Severino P et al. Solid lipid nanoparticles optimized by 22 factorial design for skin administration: cytotoxicity in NIH3T3 fibroblasts. Colloids Surfaces B Biointerfaces 171, 501–505 (2018).
  Medline CASGoogle Scholar
• 32. Zimmermann E. Electrolyte- and pH-stabilities of aqueous solid lipid nanoparticle (SLN™) dispersions in artificial gastrointestinal media. Eur. J. Pharm. Biopharm. 52(2), 203–210 (2001).
  Medline CASGoogle Scholar
• 33. Nazarzadeh E, Anthonypillai T, Sajjadi S. On the growth mechanisms of nanoemulsions. J. Colloid Interface Sci. 397, 154–162 (2013). • Addresses approach to differentiate between coalescence and Ostwald ripening effects on nano-emulsions.
  Medline CASGoogle Scholar
• 34. McClements DJ. Food emulsions: principles, practices, and techniques. CRC Press, FL, USA (2015).
  Google Scholar
• 35. Penfold J, Thomas RK, Li PX et al. Adsorption at air-water and oil-water interfaces and self-assembly in aqueous solution of ethoxylated polysorbate nonionic surfactants. Langmuir 31(10), 3003–3011 (2015).
  Medline CASGoogle Scholar
• 36. Thompson KL, Derry MJ, Hatton FL, Armes SP. Long-term stability of n -alkane-in-water pickering nanoemulsions: effect of aqueous solubility of droplet phase on ostwald ripening. Langmuir 34(31), 9289–9297 (2018).
  Medline CASGoogle Scholar
• 37. Dashnau JL, Nucci NV, Sharp KA, Vanderkooi JM. Hydrogen bonding and the cryoprotective properties of glycerol/water mixtures. J. Phys. Chem. B. 110(27), 13670–13677 (2006).
  Medline CASGoogle Scholar
• 38. Lee CM, Kubicki JD, Fan B, Zhong L, Jarvis MC, Kim SH. Hydrogen-bonding network and OH stretch vibration of cellulose: comparison of computational modeling with polarized IR and SFG spectra. J. Phys. Chem. B. 119(49), 15138–15149 (2015).
  Medline CASGoogle Scholar
• 39. Coward JL. FTIR spectroscopy of synthesized racemic nonacosan-10-ol: a model compound for plant epicuticular waxes. J. Biol. Phys. 36(4), 405–425 (2010).
  Medline CASGoogle Scholar
• 40. Whittinghill JM, Norton J, Proctor A. A fourier transform infrared spectroscopy study of the effect of temperature on soy lecithin-stabilized emulsions. J. Am. Oil Chem. Soc. 76(12), 1393–1398 (1999).
  CASGoogle Scholar
• 41. Mishra V, Bansal K, Verma A et al. Solid lipid nanoparticles: emerging colloidal nano drug delivery systems. Pharmaceutics 10(4), 191 (2018).
  CASGoogle Scholar
• 42. Bhuiyan AKMMH, Waters LJ. Permeation of pharmaceutical compounds through silicone membrane in the presence of surfactants. Colloids Surfaces A Physicochem. Eng. Asp. 516, 121–128 (2017).
  CASGoogle Scholar
• 43. Rodríguez-López L, Shokry DS, Cruz JM, Moldes AB, Waters LJ. The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane. Colloids Surfaces B Biointerfaces. 176, 456–461 (2019).
  Medline CASGoogle Scholar
• 44. Yuan JS, Yip A, Nguyen N, Chu J, Wen XY, Acosta EJ. Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions. Int. J. Pharm. 392(1–2), 274–284 (2010).
  Medline CASGoogle Scholar
• 45. Baspinar Y, Borchert H-H. Penetration and release studies of positively and negatively charged nanoemulsions – is there a benefit of the positive charge? Int. J. Pharm. 430(1–2), 247–252 (2012).
  Medline CASGoogle Scholar
• 46. Tavares L, Shevchuk I, Alfonso M, Marcenyac G, Valia K. Loratadine transdermal device and methods. EP1335689A1 1–40 (2016).
  Google Scholar
• 47. Walstra P. Principles of emulsion formation. Chem. Eng. Sci. 48(2), 333–349 (1993).
  CASGoogle Scholar
• 48. Li PH, Chiang BH. Process optimization and stability of d-limonene-in-water nanoemulsions prepared by ultrasonic emulsification using response surface methodology. Ultrason. Sonochem. 19(1), 192–197 (2012). • Describes the effect of ultrasound role in the preparation of nanoemulsions.
  Medline CASGoogle Scholar
• 49. Saberi AH, Fang Y, McClements DJ. Fabrication of vitamin E-enriched nanoemulsions: factors affecting particle size using spontaneous emulsification. J. Colloid Interface Sci. 391(1), 95–102 (2013).
  Medline CASGoogle Scholar
• 50. Manev ED, Pugh RJ. Diffuse layer electrostatic potential and stability of thin aqueous films containing a nonionic surfactant. Langmuir 7(10), 2253–2260 (1991).
  CASGoogle Scholar
• 51. Wang L, Mutch KJ, Eastoe J, Heenan RK, Dong J. Nanoemulsions prepared by a two-step low-energy process. Langmuir 24(12), 6092–6099 (2008).
  Medline CASGoogle Scholar
• 52. Wang L, Tabor R, Eastoe J, Li X, Heenan RK, Dong J. Formation and stability of nanoemulsions with mixed ionic–nonionic surfactants. Phys. Chem. Chem. Phys. 11(42), 9772 (2009).
  Medline CASGoogle Scholar
• 53. Kim H-J, Decker EA, McClements DJ. Impact of protein surface denaturation on droplet flocculation in hexadecane oil-in-water emulsions stabilized by β-lactoglobulin. J. Agric. Food Chem. 50(24), 7131–7137 (2002).
  Medline CASGoogle Scholar
• 54. Kim H-J, Decker EA, McClements DJ. Role of postadsorption conformation changes of β-lactoglobulin on its ability to stabilize oil droplets against flocculation during heating at neutral pH. Langmuir 18(20), 7577–7583 (2002).
  CASGoogle Scholar
• 55. Komaiko JS, Mcclements DJ. Formation of food-grade nanoemulsions using low-energy preparation methods: a review of available methods. Compr. Rev. Food Sci. Food Saf. 15(2), 331–352 (2016).
  Medline CASGoogle Scholar
• 56. Jafari SM, Assadpoor E, He Y, Bhandari B. Re-coalescence of emulsion droplets during high-energy emulsification. Food Hydrocoll. 22, 1191–1202 (2008).
  CASGoogle Scholar
• 57. Kiefer J, Frank K, Schuchmann HP. Attenuated total reflection infrared (ATR-IR) spectroscopy of a water-in-oil emulsion. Appl. Spectrosc. 65(9), 1024–1028 (2011).
  Medline CASGoogle Scholar
• 58. Abd E, Benson H, Roberts M, Grice J. Minoxidil skin delivery from nanoemulsion formulations containing eucalyptol or oleic acid: enhanced diffusivity and follicular targeting. Pharmaceutics 10(1), 19 (2018).
  Google Scholar
• 59. Shaker DS, Ishak RAH, Ghoneim A, Elhuoni MA. Nanoemulsion: a review on mechanisms for the transdermal delivery of hydrophobic and hydrophilic drugs. Sci. Pharm. 87(3), 17 (2019).
  CASGoogle Scholar
• 60. Moss GP, Gullick DR, Cox PA et al. Design, synthesis and characterization of captopril prodrugs for enhanced percutaneous absorption. J. Pharm. Pharmacol. 58(2), 167–177 (2006). • Highlights the effect of physicochemical properties of drugs on skin permeation.
  Medline CASGoogle Scholar