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Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India

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Vijaya Madhyanapu Golla

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India

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Rahul Khemchandani

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India

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Roshitha Kunnath Ramachandran

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India

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Gananadhamu Samanthula

*Author for correspondence: Tel.: +91 918 282 6407;

E-mail Address: gana.niperhyd@gov.in

https://orcid.org/0000-0002-6389-5994

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 500037, India

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Published Online:6 Mar 2024https://doi.org/10.4155/bio-2023-0256

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Abstract

Covalent organic frameworks (COFs) have much potential in the field of analytical separation research due to their distinctive characteristics, including easy modification, low densities, large specific surface areas and permanent porosity. This article provides a historical overview of the synthesis and broad perspectives on the applications of COFs. The use of COF-based membranes in gas separation, water treatment (desalination, heavy metals and dye removal), membrane filtration, photoconduction, sensing and fuel cells is also covered. However, these COFs also demonstrate great promise as solid-phase extraction sorbents and solid-phase microextraction coatings. In addition to various separation applications, this work aims to highlight important advancements in the synthesis of COFs for chiral and isomeric compounds.

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Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Received 9 December 2023

Accepted 31 January 2024

Published online 6 March 2024

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Acknowledgments

The authors are grateful to the National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India, for its valuable insights in preparing the manuscript. The authors thank the Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Government of India, New Delhi, for a NIPER fellowship award. This manuscript bears the NIPER-Hyderabad communication number: NIPER-H/2023/.

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The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

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No writing assistance was utilized in the production of this manuscript.

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Covalent organic frameworks: spotlight on applications in the pharmaceutical arena

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