We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×

miRNA nanotherapeutics: potential and challenges in respiratory disorders

    Meenu Mehta

    Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia

    Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia

    ,
    Dinesh K Chellappan

    School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia

    ,
    Peter R Wich

    School of Chemical Engineering, University of New South Wales, Sydney, NSW, 2052, Australia

    Centre for NanoMedicine, University of New South Wales, Sydney, NSW, 2052, Australia

    ,
    Nicole G Hansbro

    Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia

    School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW, 2007, Australia

    Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia

    ,
    Philip M Hansbro

    Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia

    School of Life Sciences, Faculty of Science, University of Technology Sydney (UTS), Ultimo, NSW, 2007, Australia

    Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia

    &
    Kamal Dua

    *Author for correspondence:

    E-mail Address: Kamal.Dua@uts.edu.au

    Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia

    Centre for Inflammation, Centenary Institute, Sydney, NSW, 2050, Australia

    Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW, 2305, Australia

    School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India

    Published Online:https://doi.org/10.4155/fmc-2020-0066
    Free first page

    References

    • 1. Wisnivesky J, de-Torres JP. The global burden of pulmonary diseases: most prevalent problems and opportunities for improvement. Ann. Glob. Health 85(1), 1–2 (2019).
    • 2. Dua K, Chellappan DK, Singhvi G, de Jesus Andreoli Pinto T, Gupta G, Hansbro PM. Targeting microRNAs using nanotechnology in pulmonary diseases. Panminerva Med. 60(4), 230–231 (2018).
    • 3. Wadhwa R, Aggarwal T, Malyla V et al. Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease. J. Cell. Physiol. 234(10), 16703–16723 (2019).
    • 4. Maltby S, Plank M, Tay HL, Collison A, Foster PS. Targeting microRNA function in respiratory diseases: mini-review. Front. Physiol. 7, 21 (2016).
    • 5. Weinstein S, Peer D. RNAi nanomedicines: challenges and opportunities within the immune system. Nanotechnology 21(23), 232001 (2010).
    • 6. Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23(4), 457–462 (2005).
    • 7. Awasthi R, Rathbone MJ, Hansbro PM, Bebawy M, Dua K. Therapeutic prospects of microRNAs in cancer treatment through nanotechnology. Drug Deliv. Transl. Res. 8(1), 97–110 (2018).
    • 8. Dua K, Hansbro NG, Foster PS, Hansbro PM. MicroRNAs as therapeutics for future drug delivery systems in treatment of lung diseases. Drug Deliv. Transl. Res. 7(1), 168–178 (2017).
    • 9. McCully M, Conde J, VB P, Mullin M, Dalby MJ, Berry CC. Nanoparticle-antagomiR based targeting of miR-31 to induce osterix and osteocalcin expression in mesenchymal stem cells. PLoS ONE 13(2), e0192562 (2018).
    • 10. Sharma A, Kumar M, Ahmad T et al. Antagonism of mmu-mir-106a attenuates asthma features in allergic murine model. J. Appl. Physiol. 113(3), 459–464 (2012).
    • 11. Dua K, Rapalli VK, Shukla SD et al. Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: emerging need for novel drug delivery approaches. Biomed. Pharmacother. 107, 1218–1229 (2018).
    • 12. Riley MK, Vermerris W. Recent advances in nanomaterials for gene delivery – a review. Nanomaterials (Basel) 7(5), doi:10.3390/nano7050094 (2017).
    • 13. Davies OR, Head L, Armitage D et al. Surface modification of microspheres with steric stabilizing and cationic polymers for gene delivery. Langmuir 24(14), 7138–7146 (2008).
    • 14. Mohamed A, Kunda NK, Ross K, Hutcheon GA, Saleem IY. Polymeric nanoparticles for the delivery of miRNA to treat chronic obstructive pulmonary disease (COPD). Eur. J. Pharm. Biopharm. 136, 1–8 (2019).
    • 15. Moro M, Di Paolo D, Milione M et al. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor growth in patient-derived xenografts lung cancer models. J. Control. Release 308, 44–56 (2019).
    • 16. McKiernan PJ, Cunningham O, Greene CM, Cryan SA. Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnology. Int. J. Nanomedicine 8, 3907–3915 (2013).
    • 17. Kasinski AL, Kelnar K, Stahlhut C et al. A combinatorial microRNA therapeutics approach to suppressing non-small-cell lung cancer. Oncogene 34(27), 3547–3555 (2015).
    • 18. Trang P, Wiggins JF, Daige CL et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol. Ther. 19(6), 1116–1122 (2011).
    • 19. Shi S, Han L, Deng L et al. Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J. Control. Release 194, 228–237 (2014).
    • 20. Song Y, Zhou B, Du X et al. Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small-cell lung cancer (NSCLC). Biomed. Pharmacother. 125, 109561 (2020).